Effect and Clinical Significance of Neoadjuvant Chemotherapy on Expression of ER,PR and EphA2 in Breast Cancer

Objective To study the influence of neoadjuvant chemotherapy on expression of ER、PR and EphA2 in breast cancer and their clinical significance. Methods The expressions of ER、PR and EphA2 of 52 patients with breast cancer were investigated by SP immunohistochemical method before and after Neoadjuvant Chemotherapy. Results The expressions of ER、PR and EphA2 were significantly related to treatment response (P<0.05).The positive expression rate of EphA2 after neoadjuvant chemotherapy was significantly lower than that before the treatment(P<0.05),but the difference of ER,PR before and after neoadjuvant chemotherapy were insignificant(P＞0.05). Conclusion Neoadjuvant chemotherapy could inhibit tumor proliferation and induce tumor cell apoptosis，and significantly decrease the expression of EphA2,but it could not reduce the expression of ER and PR significantly.