Detection and Significance of Abnormality FHIT Gene in Cutis SCC

Objective To detect the deletion and mutation of exon 5 and 8 of fagile histidine triad gene （FHIT） in cutis SCC, and to analyze the role of the abnormality in the carcinogenesis of cutis cancer. Methods The deletion and mutations of exon 5 and 8 of FHIT gene were detected in 10 cutis CSCC tissues by PCR-SSCP methods. Results Deletion of exon 5 was observed in 3 out of 10 SCC tumor samples, and the deletion of exon 8 is 8 out of 10 CSCC. No mutation was found at exon 5 and 8 of FHIT gene. Conclusion Deletion of exon 5 and 8 was observed in cutis SCC and no mutation was found. The abnormality may play a role in the pathogenesis of cutis tumor SCC which deserve further research on the concrete pathogenesis.