Clinical Observation of Concurrent Chemoradiotherapy in Treating Lung Cancer Complicated Vertebral Metastasis of 30 Cases

Objective To explore the clinical efficacy and adverse reaction of concurrent chemoradiotherapy on lung cancer complicated vertebral metastasis. Methods Thirty cases of NSCLC complicated vertebral metastasis，ECOG remark 0~2 score，underwent DP（Docetaxel 75mg/m²+DDP 75mg/m²，iv drip，d1）regimen chemotherapy，concurrent vertebras external irradiation，applied conventional radiotherapy，2Gy/fraction/day，5 fractions/week，for 4 weeks with total dose 40Gy. Results After the treatment，the motor function of lower extremity was improved and pain relieved，both showed significant differences（P＜0.05），local control rate of 1 and 2 year was 60.7%，46.4%，survival rate of 1 and 2 year was 53.5%，35.7%，median survival time was 14 months，the major toxicity was myelosupression，nausea/vomiting and alopecia. Conclusion DP regimen chemotherapy combined concurrent vertebras radiotherapy in treating spinal cord compression shows good efficacy，improves the quality of life and the toxicity can be tolerated.