Expression and Clinical Significance of P-gp、GST-π and TopoⅡin Breast Cancer and Their Lymph-node Metastasis Tumors

Objective 　To investigate the protein expressions and relationship of P2gp, GST2π and Topo Ⅱin breast cancer and their lymph2node metastasis tumor. Methods 　High sensitive SP immunohistochemi2 cal method was used to detect the protein expressions of P2gp, GST2πand Topo Ⅱin 70 breast cancers and their lymph2node metastasis tumors (36 with lymphatic metastasis) . Results 　(1) The expressions of P2 gp, GST2πin breast cancers with lymphatic metastasis was higher than those without lymphatic metasta2 sis ( P = 0. 043, P = 0. 012), but the expression of Topo Ⅱ had no difference between the two groups. (2) The expressions of GST2π、To Po Ⅱwere significantly associated with lymphatic metastasis ( P = 0. 001, P = 0. 01) . However, the expression of P2gp was not associated with lymphatic metastasis. Conclusion 　 (1) There was a significant relationship between the higher expression of P2gp, GST2π and the axillary lymph node involvement . (2) The drug2resistance of breast cancers was not as same as their lymph2node metastatic tumors.