Significance of HPV16 E7 and Brn-3a Expression in Cervical Neoplasia

Objective To examine the potential of HPV16 E7 and Brn-3a as a biomarker for cervical premalignant lesions in ThinPrep smears,and search for the identification of specific biomarkers for dysplastic epithelial cells of the cervix as a new examine ways. Methods Random sample 71 patients to be examined tissue test under the colpomicroscope.RT-PCR was used to detect the mRNA of HPV16 E7 and Brn-3a in 71 ThinPrep liquid-based smears specimens. Results In cytologic and pathologic diagnose grades;the positive rates ...