Experimental study on the mechanism of decrease in bone healing capacity after irradiation

Objective To investigate the mechanism of decrease in bone healing capacity after irradiation. Methods After the right hind shank of rabbits was irradiated with 60 Co γ ray at a dose of 15Gy,. the transverse fracture of the upper-middle tibia was inflicted with electric saw. Then, the Half-ring External Fixator was placed. Unirradiation group was called the control group. The therapeutic effects were observed with histological examination, BMP-McAb and TGF-β1-McAb immunohistochemistry, measuremen...