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ZHAI Guang, YUAN Xian-hou, QI Jin-qin. Deletion and 5'CPG island Methylation of p15 Gene in Brain Glioma[J]. Cancer Research on Prevention and Treatment, 2001, 28(04): 267-269. DOI: 10.3971/j.issn.1000-8578.1774
Citation: ZHAI Guang, YUAN Xian-hou, QI Jin-qin. Deletion and 5'CPG island Methylation of p15 Gene in Brain Glioma[J]. Cancer Research on Prevention and Treatment, 2001, 28(04): 267-269. DOI: 10.3971/j.issn.1000-8578.1774
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Deletion and 5'CPG island Methylation of p15 Gene in Brain Glioma

  • Department of Neurosurgery, the First Affiliated Hospital Henan Medical University, Zhengzhou 450052, China

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  • Corresponding author:

    ZHAI Guang

  • Received Date: April 06, 2000
  • Revised Date: May 30, 2001
    Abstract
  • Objective To investigate the abnormality of p15 gene in brain glioma and the correlation or it with occurrence or malignant progression of brain glioma. Methods Deletion and 5′CPG island methylation of p15 gene were detected by methods of PCR and PCR based methylation in 56 cases of brain glioma. Results Out of the 43 cases of high grade glioma,14 cases were found to have homozygous deletion of p15E1,while none of the 13 cases of low grade glioma was found to have deletion of p15E1 (P<0.05) .Methylati...
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    QI Jin-qin

    • Department of Neurosurgery, the First Affiliated Hospital Henan Medical University, Zhengzhou 450052, China

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