Overexpression p73 Gene Inhibit VEGF, bFGF Expression in Lung Adenocarcinoma Cell

Objective 　To study the effect of overexpression p73 gene on VEGF, bFGF expression in lung adenocarcinoma cell. Methods 　p73 gene was t ransferred into A549 cell and H1299 cell by liposome and the positive cell clones were chosen by G418. The VEGF and bFGF mRNA expression were detected by RT-PCR, protein expression were detected by western-blot . Results 　The VEGF, bFGF mRNA and protein expression in A549 cell and H1299 cell were decreased af ter t ransferred p73 gene ( P < 0. 05) . Conclusion 　Overexpression p73 gene can inhibit the VEGF and bFGF expression in lung adenocarcinoma, so it can inhibit the angiogenesis in lung adenocarcinoma.