Effect of Urinary Trypsin Inhibitor on the Expression of Urokinase-type Plasminogen Activator in Human Bladder Cancer Cell T24 in Vitro

Objective To study the effect of urinary trypsin inhibitor (UTI) on the expression of urokinase-type plasminogen activator (uPA) in human transitional cell bladder cancer cell T24 in vitro and investigate the mechanism of UTI inhibiting bladder tumor metastasis and invasion. Methods Semi-quantities RT-PCR and immunohistochemical techniques were used to examine the expression of uPA in T24 cell after different dose of UTI were added to T24 cell cultured in vitro. Results The expression of uPA was suppre...