Clinicopathologic Features of 1 Case of Composite Haemangioendothel ioma and Relative Literatures Review

Objective 　To explore the clinicopathologic features of one case of composite haemangioendothelioma and its immunohistochemistry expression. Methods 　Monoclonal antibodies including CD31, CD34, Factor VIII, VWF(von Willebrand Factor), PCK, Vimentin and EMA was used to detect the expression of this case and the relative literatures were reviewed. Results 　Macroscopy showed that the speciman was a piece of skeletal muscle with fascia. Thirty-one gray nodules whose diameter were 0. 6 to 2. 5 cm could be seen. Microscopy : the neoplasm was consisted of complex admixture of retiform haemangioendothelioma, epithelioid haemangioendothelioma and spindle cell haemangioma. The lesions are positive for vascular markers ( CD31, CD34, Factor VIII, VWF ) . Conclusion 　The composite haemangioendothelioma was a very rare low-grade malignant tumor whose component s were diverse. Immunohistochemistry expressions could help us diagnose the tumor.