^{Signif icance of TGF-β1, TβRⅡand cyclinD1 Expression in Colorectal Carcinoma}

Objective 　To investigate the role of TGF-β1, TβR Ⅱ,cyclinD1 expression in colorectal carcinoma. Methods 　SP immunostaining technique was used to examine the expression of TGF-β1, TβR Ⅱand cyclinD1 in colorectal adenomas and carcinomas. Results 　TGF-β1 was expressed positively in 28. 6 %colorectal adenoma tissues while 57. 1 % in carcinoma ( P < 0. 05 ) ; TβR Ⅱ was expressed positively 51. 8 % in colorectal carcinoma tissues which was lower than adenoma tissues ( P < 0. 01) ; The expression of TGF-β1 、TβR Ⅱin colorectal tissues was associated with colorectal carcinoma infilt ration depth, lymph node metastasis ; A negative correlation was observed between the expression of TβR Ⅱ and that of cyclinD1 ( P < 0. 05) . Conclusion 　The overexpression of TGF2β1 was highly related to the invasion or metastasis of colorectal carcinoma ; Decreased expression of TβR Ⅱ was helpful not only to enhance cell growth resistance to TGF2β1 but increase the invasion of colorectal carcinoma ; cyclinD1 may played a role in the resistance of TGF-β1.