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LI Zhi-ge, SONG Xiang-qun, YU Qi-tao, ZENG Ai-ping, ZHOU Da, HE Jian-bo, WANG Hui-lin. The Preliminary Observation of Trastuzumab-based Combination Chemotherapy in Salvage Treatment of Her-2 Overexpressing in Metastatic Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2006, 33(09): 673-674. DOI: 10.3971/j.issn.1000-8578.1315
Citation: LI Zhi-ge, SONG Xiang-qun, YU Qi-tao, ZENG Ai-ping, ZHOU Da, HE Jian-bo, WANG Hui-lin. The Preliminary Observation of Trastuzumab-based Combination Chemotherapy in Salvage Treatment of Her-2 Overexpressing in Metastatic Breast Cancer[J]. Cancer Research on Prevention and Treatment, 2006, 33(09): 673-674. DOI: 10.3971/j.issn.1000-8578.1315
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The Preliminary Observation of Trastuzumab-based Combination Chemotherapy in Salvage Treatment of Her-2 Overexpressing in Metastatic Breast Cancer

  • Department of Chemotherapy; Tumor Hospital of Guangxi Medical University; Nanning 530021; China

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    LI Zhi-ge

  • Received Date: November 20, 2005
  • Revised Date: April 02, 2006
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  • Objective To observe the effects and toxicity of trastuzumab-based combination regimen comprising vinorelbine,fluorouracil and cisplatin in 15 patients with Her-2 positive metastatic breast cancer. Methods Treatment consisted of Trastuzumab(4mg/kg on day 0,then 2mg/kg weekly);vinorelbine (25mg/m2 on day 1 and 5);cisplantin(20mg/m2 on day 1～3) and fluorouracil (5-Fu) 1.0 on day 1～3. Results The overall response rate was 73%,including 6 complete( 40.0%) and 5 partial responses(33%).Median survival was 13 months...
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