Analysis of the Value of p53,p21wafl,and PCNA for Lung Cancer Diagnosis

Objective To seek potential biomarkers for lung cancer diagnosis. Methods The expression status of p53,p21wafl and PCNA in lung cancer and benign pulmonary diseases were studied and the diagnostic value of these three markers was analysed by case-control study. Results (1) The positive rates of p53,p21 wafl and PCNA expression in lung cancer were all significantly higher than those in benign pulmonary diseases.(2) The positive likelihood ratio of p53 was 13.97.Its specificity was significantly higher than tha...