The Value on nm23-H1 Predication of Metastatic Potential in Colorectal Carcinomas

Objectrive Most deaths from colorectal carcinoma are due to metastasis.However,there is no reliable metastatic potential indicator to date.This study was performed to investigate the potentials of nm23-H1 as metastatic potential markers in colorectal cancer.Method Immunohistologic staining for nm23-H1 was performed on archival materials from 58 patients with colorectal carcinomas by SP assay.The relationship between nm23-H1 expression in tumor tissues and clinicopathological parameters was analyzed using SSPS software. Results 62.1% of patients with colorectal cancer expressed elevated levels of nm23-H1,and correlated with decreasing tumor stage(P=0.01),and had a negative relation with lymph node and liver metastasis(P=0.02087，0.00376，respectively).nm23-H1 as a reliable metastatic potential marker,overexpression of nm23-H1 contributed to good prognosis(P=0.0002) Conclusion nm23-H1 is a sensitive marker for predication of metastatic potential in colorectal carcinomas.