Clinical Significance of WISP-1 and VEGF-A Expression Levels in Elderly Patients with Esophageal Squamous Cell Carcinoma

LI Chenlu; HUANG Junxing

doi:10.3971/j.issn.1000-8578.2024.24.0348

Cancer Research on Prevention and Treatment > 2024 > 51(10): 858-863. > DOI: 10.3971/j.issn.1000-8578.2024.24.0348

LI Chenlu, HUANG Junxing. Clinical Significance of WISP-1 and VEGF-A Expression Levels in Elderly Patients with Esophageal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2024, 51(10): 858-863. DOI: 10.3971/j.issn.1000-8578.2024.24.0348

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Clinical Significance of WISP-1 and VEGF-A Expression Levels in Elderly Patients with Esophageal Squamous Cell Carcinoma

LI Chenlu,
HUANG Junxing^, ,

Department of Oncology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou 225300, China

Funding: Scientific Research Program of Jiangsu Provincial Health Commission (No. BJ20012)

More Information

Corresponding author:
HUANG Junxing, E-mail: hjxtz@sina.cn
Received Date: April 18, 2024
Revised Date: July 30, 2024
Accepted Date: July 30, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the clinical value of WNT1 inducible signaling pathway protein 1 (WISP-1) and vascular endothelial growth factor-A (VEGF-A) as novel molecular markers of esophageal squamous cell carcinoma (ESCC) in elderly patients.
Methods
Elderly patients with ESCC were divided into 65-70 years old group and >70 years old group. Immunohistochemical staining and RT-PCR were used to detect the expression levels of WISP-1 and VEGF-A proteins and mRNAs, respectively. Log rank test was used to analyze correlation between clinicopathological features and prognosis of ESCC in the elderly.
Results
The positive expression rate of WISP-1 in ESCC tissues was significantly higher than that in para-cancer tissues (53.33% vs. 35.42%, P=0.045). The positive expression rate of WISP-1 in patients over 70 years old and with lymph node metastasis was significantly higher than that in patients aged 65-70 years and without lymph node metastasis (P=0.047 and 0.032). The positive expression rate of VEGF-A protein in ESCC tissues was significantly higher than that in para-cancer tissues (50.00% vs. 20.83%, P=0.001). The positive expression rate of VEGF-A in patients with depth of infiltration T3-T4 stage, lymph node metastasis, and TNM Ⅲ-Ⅳ stage was significantly higher than that in patients with T1-T2 stage, no lymph node metastasis, and Ⅰ-Ⅱ stage (P=0.030, 0.006, and 0.010, respectively). The mRNA expression levels of these two molecules were significantly higher in ESCC tissues than in para-cancer tissues (P<0.05), and the results of univariate analysis showed that the expression levels of WISP-1 and VEGF-A were correlated with the prognosis of ESCC in the elderly (P<0.05). The results of multivariate analysis showed that lymph node metastasis was the independent risk factor affecting the prognosis of elderly patients with ESCC.
Conclusion
WISP-1 and VEGF-A are associated with malignant behavior in elderly patients with ESCC. The expression of WISP-1 increased with age, and it has potential as a novel molecular marker of ESCC in elderly patients.
- Elderly,
- Esophageal squamous cell carcinoma,
- WISP-1,
- VEGF-A

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Competing interests: The authors declare that they have no competing interests.

References (20)

References

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Clinical Significance of WISP-1 and VEGF-A Expression Levels in Elderly Patients with Esophageal Squamous Cell Carcinoma