Advances of ¹²⁵I Radioactive Particle Chain Intracavitary Brachytherapy

The radioactive particle chain is a linear array of ¹²⁵I particles and placed in a tubular conduit. The dose distribution of the particle chain is similar to the shape of a cylinder. It may be adapted to the tumors in the lumen and exerts the radiotherapy effect that may not be achieved by single particles. This article aims to review the history of ¹²⁵I radioactive particle chains, dose distribution, placement methods and clinical application.