1999 Vol. 26 No. 6
1999, 26(6): 401-402.
Abstract：
Objective To detem}ine the mle of Helicobacter pylori(HP) in the development of gastric cancer and gastric precancemus lesions. Methods the point mutation of C-Ha-Ras gene was detected by polymerase chain reaction-single strand conformation polymorphism analysis-direct sequence(PCR-SSCP-Sequence ) Results the mutational rates of C-Ha-Ras gene in Hp positive patients were significantly higher than those in Hp negative patients.For gastric cancer patients, the mutational rate of P53 gene in Hp positive patients were significantly higher than those of Hp negative patients. Conclusion Hp infection may be in relation with gastrocar- cinogenesis, the gene mutation may play a role in Hp related gastric cancer.
Objective To detem}ine the mle of Helicobacter pylori(HP) in the development of gastric cancer and gastric precancemus lesions. Methods the point mutation of C-Ha-Ras gene was detected by polymerase chain reaction-single strand conformation polymorphism analysis-direct sequence(PCR-SSCP-Sequence ) Results the mutational rates of C-Ha-Ras gene in Hp positive patients were significantly higher than those in Hp negative patients.For gastric cancer patients, the mutational rate of P53 gene in Hp positive patients were significantly higher than those of Hp negative patients. Conclusion Hp infection may be in relation with gastrocar- cinogenesis, the gene mutation may play a role in Hp related gastric cancer.
1999, 26(6): 403-405.
Abstract：
Objective To determine the role of Helicobacter pylori(HP) in the development of gastric cancer and gastric precancerous lesions. Methods the point mutation of C-Ha-Ras gene was detected by polymerase chain reaction-single strand conformation polymorphism analysis-direct sequence (PCR-SSCP-Sequence) Resalts the mutational rates of C-Ha-Ras gene in Hp positive patients were significantly higher than those in Hp negative patients.For gastric cancer patients,the mutational rate of P53 gene in Hp positive patients were significantly higher than those of Hp negative patients. Conclusion Hp infection may be in relation with gastrocarcinogenesis,the gene mutation may play a role in Hp related gastric cancer.
Objective To determine the role of Helicobacter pylori(HP) in the development of gastric cancer and gastric precancerous lesions. Methods the point mutation of C-Ha-Ras gene was detected by polymerase chain reaction-single strand conformation polymorphism analysis-direct sequence (PCR-SSCP-Sequence) Resalts the mutational rates of C-Ha-Ras gene in Hp positive patients were significantly higher than those in Hp negative patients.For gastric cancer patients,the mutational rate of P53 gene in Hp positive patients were significantly higher than those of Hp negative patients. Conclusion Hp infection may be in relation with gastrocarcinogenesis,the gene mutation may play a role in Hp related gastric cancer.
1999, 26(6): 406-408.
Abstract：
Objective To study immunologic funtions of the spleen on patients with advanced gastric cancer (AGC) and to study immunologic funtions on patients by gastrectomy and splenectomy in plateau. Methods :The levels of T cell subgroups (CD3,CD4,CD8,CD4/CD8) circulatory immune complexes(CIC) and complenmentin(CH50,C3,C4) in 32 cases with AGC were measured in different part and stage Results(1) The cell levels of CD3,CD4,CD8,CD4/CD8 in peripheral blood lymphocytes(PBL) and spleen vein blood lymphocytes (SVL)and the levels of CH50,C3,C4 on patients with AGC were less than controls one's,but the levels of CIC were higher than controls (2) The levels of CD4,CD4/CD8 in PBL were less than ones in SVL on patients with AGC.(3) Whether by gastrectomy and splenectomy (R3) or only gastrectomy (R2) the levels of CD3, CD4, CD4/CD8 increase remarkly the levels of CD8 decrease but the levels of CIC decrease remarkbly on patients with AGC.(4) During short time (10-15 days) or long time(1-2 years) the levels of T cell subgroups were not different on patients by R3 or R2. Conclusion The immunologic functions of patients were decreased by advanced gastric cancer the functions of resisting cancer were increased also the immunologic functions were improved the immunologic funcitons wrer not injureed by gastrectomy and splenectomy.
Objective To study immunologic funtions of the spleen on patients with advanced gastric cancer (AGC) and to study immunologic funtions on patients by gastrectomy and splenectomy in plateau. Methods :The levels of T cell subgroups (CD3,CD4,CD8,CD4/CD8) circulatory immune complexes(CIC) and complenmentin(CH50,C3,C4) in 32 cases with AGC were measured in different part and stage Results(1) The cell levels of CD3,CD4,CD8,CD4/CD8 in peripheral blood lymphocytes(PBL) and spleen vein blood lymphocytes (SVL)and the levels of CH50,C3,C4 on patients with AGC were less than controls one's,but the levels of CIC were higher than controls (2) The levels of CD4,CD4/CD8 in PBL were less than ones in SVL on patients with AGC.(3) Whether by gastrectomy and splenectomy (R3) or only gastrectomy (R2) the levels of CD3, CD4, CD4/CD8 increase remarkly the levels of CD8 decrease but the levels of CIC decrease remarkbly on patients with AGC.(4) During short time (10-15 days) or long time(1-2 years) the levels of T cell subgroups were not different on patients by R3 or R2. Conclusion The immunologic functions of patients were decreased by advanced gastric cancer the functions of resisting cancer were increased also the immunologic functions were improved the immunologic funcitons wrer not injureed by gastrectomy and splenectomy.
1999, 26(6): 409-411.
Abstract：
Objective To assess the relationship of human papillomavirus(HPV)and p53 with colorectal carcinoma. Methods The 33 adenocarcinomas and 15 normal mucosal samples were selected for the current study using polymerase chain reaction(PCR) and immunohistochemical techniques. Results HPV DNA was detected in 9 of 33(27.27%)carcinomas;The expression of P53 protein was found in 18 of 33(54.55%)carcinomas;No HPV DNA and P53 expression were detected in all 15 normal colorectal specimens.Out of the 9 HPV DNA positive cases,only 3 cases with p53 protein expression were found. Conclusion HPV might be involved in the pathogenesis of colorectal carcinomas (P<0.05).HPV infection and p53 mutation may play a role independently in the carcinogenesis of colorectal cancer.
Objective To assess the relationship of human papillomavirus(HPV)and p53 with colorectal carcinoma. Methods The 33 adenocarcinomas and 15 normal mucosal samples were selected for the current study using polymerase chain reaction(PCR) and immunohistochemical techniques. Results HPV DNA was detected in 9 of 33(27.27%)carcinomas;The expression of P53 protein was found in 18 of 33(54.55%)carcinomas;No HPV DNA and P53 expression were detected in all 15 normal colorectal specimens.Out of the 9 HPV DNA positive cases,only 3 cases with p53 protein expression were found. Conclusion HPV might be involved in the pathogenesis of colorectal carcinomas (P<0.05).HPV infection and p53 mutation may play a role independently in the carcinogenesis of colorectal cancer.
1999, 26(6): 412-413.
Abstract：
To establish a new method to detect the tumor marker in patients with gynecologic neoplasms.It's important to diagnose malignant tumor in women and reduce the gynecologic neoplasma incidence rate.The level of monohydroxyphenyl substance (MHP) was detected in the urine samples collected from normal women,the patients with uterine myoma, cervical neoplasm,ovarian cancer.The results showed that the content of MHP among those paticnts,there were significant difference(P<0.001).The results suggested that the high MHP level in urine may be related to the formation and development of gynecologic neoplasms.Urinary MHP could be one of the markers in early gynecologic neoplasms.
To establish a new method to detect the tumor marker in patients with gynecologic neoplasms.It's important to diagnose malignant tumor in women and reduce the gynecologic neoplasma incidence rate.The level of monohydroxyphenyl substance (MHP) was detected in the urine samples collected from normal women,the patients with uterine myoma, cervical neoplasm,ovarian cancer.The results showed that the content of MHP among those paticnts,there were significant difference(P<0.001).The results suggested that the high MHP level in urine may be related to the formation and development of gynecologic neoplasms.Urinary MHP could be one of the markers in early gynecologic neoplasms.
1999, 26(6): 414-416.
Abstract：
Objective To evaluate the diagnosis value of contents of serum and asocitic CA-50 in the cases with carcinomatous ascites. Methods The serum CA-50 content was measured by radioimmunoassay in 54 normal individuals,176 patients with carcinoma of digestive system and 160 patients with benign diseases. Results The normal value was 3.80+2.45Ku/L The content of serum CA-50 in patients with carcinoma were much higher than those of healthy people and patients with benign diseases(P＜0.001 in both),and this occurred in the early stage and became even more obverious in the late stage.Taking the normal mean value plus two times of standard deviation as positive,the positive rate was 85.8% for carcinoma of digestive system.There was only two positive in 52 normals with a fales positive rate of 3.7%. Conclusion The detection of both esrum CA-50 and ascitic CA-50 may have a certain clinical prectical value in carcinoma of the digestive system diognosis,differential diagnosis and the monitor, prediction of prognosis.
Objective To evaluate the diagnosis value of contents of serum and asocitic CA-50 in the cases with carcinomatous ascites. Methods The serum CA-50 content was measured by radioimmunoassay in 54 normal individuals,176 patients with carcinoma of digestive system and 160 patients with benign diseases. Results The normal value was 3.80+2.45Ku/L The content of serum CA-50 in patients with carcinoma were much higher than those of healthy people and patients with benign diseases(P＜0.001 in both),and this occurred in the early stage and became even more obverious in the late stage.Taking the normal mean value plus two times of standard deviation as positive,the positive rate was 85.8% for carcinoma of digestive system.There was only two positive in 52 normals with a fales positive rate of 3.7%. Conclusion The detection of both esrum CA-50 and ascitic CA-50 may have a certain clinical prectical value in carcinoma of the digestive system diognosis,differential diagnosis and the monitor, prediction of prognosis.
The Expression of nm23-H1 and p16 Suppressor Gene Protein in Thyroid Tumor and Clinical Significance
1999, 26(6): 417-419.
Abstract：
Objective To study the relationship between the expression of nm23-H1、p16 protein and thyroid carcinomas Method Immunohistochemistry was used to detect the expression of nu23-H1、p16 protein in 54 thyroid carcinomas、16 thyroid adenomas、9 nonneoplastic thyroid tissues and 12 adjacent normal tissues Results The expression of nm23-H1 and p16 was much higher in thyroid adenomas and differentiated carcinomas (P＜0.05),whereas it was much lower in undifferentiated carcinomas (P＜0.01).Positive correlation was observed between the expression of nm23-H1、p16 protein and the degree of differentiation(P＜0.01).There was no significant association betwen the expression of nm23-H1、p16 protein and the cervical lymph node metastasis,but the expression of nm23-H1 was negatively corrated with capsule invasion(P＜0.05). Conclusion The loss of nm23-H1 and p16 function may play an important role in carcinogenesis and progress of thyroid undifferentiated carcinoma.Although the expression of nm23-H1 and p16 can't be used as a marker of low metastatic potential,it may serve as a good marker for the degree of differentiation and biological behavior.
Objective To study the relationship between the expression of nm23-H1、p16 protein and thyroid carcinomas Method Immunohistochemistry was used to detect the expression of nu23-H1、p16 protein in 54 thyroid carcinomas、16 thyroid adenomas、9 nonneoplastic thyroid tissues and 12 adjacent normal tissues Results The expression of nm23-H1 and p16 was much higher in thyroid adenomas and differentiated carcinomas (P＜0.05),whereas it was much lower in undifferentiated carcinomas (P＜0.01).Positive correlation was observed between the expression of nm23-H1、p16 protein and the degree of differentiation(P＜0.01).There was no significant association betwen the expression of nm23-H1、p16 protein and the cervical lymph node metastasis,but the expression of nm23-H1 was negatively corrated with capsule invasion(P＜0.05). Conclusion The loss of nm23-H1 and p16 function may play an important role in carcinogenesis and progress of thyroid undifferentiated carcinoma.Although the expression of nm23-H1 and p16 can't be used as a marker of low metastatic potential,it may serve as a good marker for the degree of differentiation and biological behavior.
1999, 26(6): 420-421.
Abstract：
Objective Analysis the clinic characteristic.pathologic diagnosis and differential diagnosis of angiosarcoma of breast. Methods Analysis the clinic characteristic and detect the expression of F8-related antigen.Vimentin and CK of the 4 cases angiosarcoma of breast. Results Among the 4 cases,there are 2 cases have local recurrent after simple mass resection,and there are 3 cases died in 7.11.24 months after treatment respectiveely,and 1 case survived for 16 years,Conclusiton The angiosarcoma of breast is a highly malignant tumor,its prognosis related with neoplastic differential degree.
Objective Analysis the clinic characteristic.pathologic diagnosis and differential diagnosis of angiosarcoma of breast. Methods Analysis the clinic characteristic and detect the expression of F8-related antigen.Vimentin and CK of the 4 cases angiosarcoma of breast. Results Among the 4 cases,there are 2 cases have local recurrent after simple mass resection,and there are 3 cases died in 7.11.24 months after treatment respectiveely,and 1 case survived for 16 years,Conclusiton The angiosarcoma of breast is a highly malignant tumor,its prognosis related with neoplastic differential degree.
1999, 26(6): 422-423.
Abstract：
Objective To study the prognostic value of the expression of p53,c-myc and bcl-2 protein in cervical carcinoma treated with radiotherapy. Methods The expression of these three oncoproteins was detcdted immunohistochemically in 40 uncontrolled cases and 40 matched curable cases. Results The study showed that p53 oncoprotein expression was not significant difference between the two groups.c-myc expression was significantly higher in the uncontrolled group than in the curable group and bcl-2 expression lower in the former than in the latter. Conclusion It is suggested that the detection of c-myc and bcl-2 oncoproteins in cervical carcinoma before radiotherapy can be used to predict prognosis.
Objective To study the prognostic value of the expression of p53,c-myc and bcl-2 protein in cervical carcinoma treated with radiotherapy. Methods The expression of these three oncoproteins was detcdted immunohistochemically in 40 uncontrolled cases and 40 matched curable cases. Results The study showed that p53 oncoprotein expression was not significant difference between the two groups.c-myc expression was significantly higher in the uncontrolled group than in the curable group and bcl-2 expression lower in the former than in the latter. Conclusion It is suggested that the detection of c-myc and bcl-2 oncoproteins in cervical carcinoma before radiotherapy can be used to predict prognosis.
1999, 26(6): 424-425.
Abstract：
Objective To investigate expression of P53.Bcl-2.P16 and c-myc genes in ovarian epithelial tumors and relationship between expression and genesis and prognosis and its role. Methods Application Immunohistochemistic Methods ,studied expression of P53.Bcl-2.P16 and c-myc genes in ovarian epithelial tumors included 80 cases benign.26 borderline and 116 malignant tumors. Results expression on rates of P53.Bcl-2.P16 and c-myc were36.48%,27.4%,83.33% and 52.25% respectively.The expression of c-myc was increased with malignancy high,It has significant different between benign and malignant(P＜0.01).The expression rate of P16 was decreased with malignancy high and it has significance concern with tumor behavior(P＜0.01).The expression of P53.Bcl-2 and c-myc in ovarian malignant tumor were related to the stage.
Objective To investigate expression of P53.Bcl-2.P16 and c-myc genes in ovarian epithelial tumors and relationship between expression and genesis and prognosis and its role. Methods Application Immunohistochemistic Methods ,studied expression of P53.Bcl-2.P16 and c-myc genes in ovarian epithelial tumors included 80 cases benign.26 borderline and 116 malignant tumors. Results expression on rates of P53.Bcl-2.P16 and c-myc were36.48%,27.4%,83.33% and 52.25% respectively.The expression of c-myc was increased with malignancy high,It has significant different between benign and malignant(P＜0.01).The expression rate of P16 was decreased with malignancy high and it has significance concern with tumor behavior(P＜0.01).The expression of P53.Bcl-2 and c-myc in ovarian malignant tumor were related to the stage.
1999, 26(6): 426-427.
Abstract：
Objective To study the combined curative effect of Chinese medicines and chemical drugs on advanced gastric cancers and the side effects of chemotherapy. Methods 52 cases of patients with advanced gastric cancer were treated with AMF or TMF and Chinese medicines. Results The total effective rate was 53%;The side effect (＜Ⅱ° was 92% on gastric-intestinal tract and 92% on peripheral blood system. Conclusion Compared with effective rate (42%) of chemotherapy alone published in literature,the combined curative effect of Chinese medicines and chemotherapy was better and its side effects were reduced.
Objective To study the combined curative effect of Chinese medicines and chemical drugs on advanced gastric cancers and the side effects of chemotherapy. Methods 52 cases of patients with advanced gastric cancer were treated with AMF or TMF and Chinese medicines. Results The total effective rate was 53%;The side effect (＜Ⅱ° was 92% on gastric-intestinal tract and 92% on peripheral blood system. Conclusion Compared with effective rate (42%) of chemotherapy alone published in literature,the combined curative effect of Chinese medicines and chemotherapy was better and its side effects were reduced.
1999, 26(6): 430-431.
Abstract：
28 cases of adenocarcinoma of bladder wre treated from 1978 to 1997.On pathological studies,23 were primary adenocarcinoma,while the other 5 were of urachus origin.The clinical,cystoscopic and cystographic manifestations of the disease were presented.The aetiology of the tumour,early diagnosis and therapeutic principl were analysed and discussed.Extensive partial cystectomy of radical total cystectomy was advocated with postoperative radio and chemo-therapy.The 5 year-survival rate of this series has been 23.1%.
28 cases of adenocarcinoma of bladder wre treated from 1978 to 1997.On pathological studies,23 were primary adenocarcinoma,while the other 5 were of urachus origin.The clinical,cystoscopic and cystographic manifestations of the disease were presented.The aetiology of the tumour,early diagnosis and therapeutic principl were analysed and discussed.Extensive partial cystectomy of radical total cystectomy was advocated with postoperative radio and chemo-therapy.The 5 year-survival rate of this series has been 23.1%.
1999, 26(6): 432-433.
Abstract：
Objective To discuss the value of lactic dehydrogenase activity and isoenzmes in differentiating malignant and tuberculous effusion. Methods Lactic dehydrogenase activities and isoenzymes in serum and pleural fluid was determined simultaneously in 100 patients with malignancy and 81 patients with tubercuiosis. Results Lactic dehydrogenase levels and isoenzymes in pleural fluid between two groups did not correlate significantly (P>0.05).The ratio of lactic dehydrogenase activity in pleural fluid to sera between two groups did not correlate significantly (P>0.05). Conclusion Detecting lactic dehydrogenase levels and isoenzymes of pleural effusion might be helpless for differentiating malignant and tuberculous effusion.
Objective To discuss the value of lactic dehydrogenase activity and isoenzmes in differentiating malignant and tuberculous effusion. Methods Lactic dehydrogenase activities and isoenzymes in serum and pleural fluid was determined simultaneously in 100 patients with malignancy and 81 patients with tubercuiosis. Results Lactic dehydrogenase levels and isoenzymes in pleural fluid between two groups did not correlate significantly (P>0.05).The ratio of lactic dehydrogenase activity in pleural fluid to sera between two groups did not correlate significantly (P>0.05). Conclusion Detecting lactic dehydrogenase levels and isoenzymes of pleural effusion might be helpless for differentiating malignant and tuberculous effusion.
1999, 26(6): 434-435.
Abstract：
In order to observe the effect of BCG-PSN on cellular immune,fourty-five cases of breast cancer after surgery were treated with BCG-PSN in addition to routine treatment (Group A).They were compared with 25 cases who receive routine treatment alone (Group B).The result shows the ratio of lympho cyte subgroup CD4/CD8 gets higher in group A and remainds in group B.It suggests that BCG-PSN is able to activeate T lmphocyte subgroup and improne cellular immne.Therefore,BCG-PSN may be used a good auxilliary therapy for breast cancer patient.
In order to observe the effect of BCG-PSN on cellular immune,fourty-five cases of breast cancer after surgery were treated with BCG-PSN in addition to routine treatment (Group A).They were compared with 25 cases who receive routine treatment alone (Group B).The result shows the ratio of lympho cyte subgroup CD4/CD8 gets higher in group A and remainds in group B.It suggests that BCG-PSN is able to activeate T lmphocyte subgroup and improne cellular immne.Therefore,BCG-PSN may be used a good auxilliary therapy for breast cancer patient.
1999, 26(6): 435-436.
Abstract：
Objective To study the isoenzyme differences between normal and elevated serum lactic dehydrogenase(LDH)in different tumor patients. Methods We determined the serum LDH isoenzyme activitise in 309 tumor patients with normal LDH and 276 with elevated LDH,and in 37 normal controls using agarose gel electrophoresis. Results Different tumor patients with normal serum LDH activities had elevated LDH3 activity and there was significant difference between this group and the normal control.Patients with elevated serum LDH activities had elevated LDH3,LDH4,and LDH5 activities and there was significant difference compared with the normal control. Conclusion LDH isoenzymes may be used as a reference diagnosis index for the malignant tumor patients,Especially,the tumor patients with normal;LDH acticities had abnormal LDH isoenzyme pattern.Elevated LDH3 was one of the early characteristics of tumors.
Objective To study the isoenzyme differences between normal and elevated serum lactic dehydrogenase(LDH)in different tumor patients. Methods We determined the serum LDH isoenzyme activitise in 309 tumor patients with normal LDH and 276 with elevated LDH,and in 37 normal controls using agarose gel electrophoresis. Results Different tumor patients with normal serum LDH activities had elevated LDH3 activity and there was significant difference between this group and the normal control.Patients with elevated serum LDH activities had elevated LDH3,LDH4,and LDH5 activities and there was significant difference compared with the normal control. Conclusion LDH isoenzymes may be used as a reference diagnosis index for the malignant tumor patients,Especially,the tumor patients with normal;LDH acticities had abnormal LDH isoenzyme pattern.Elevated LDH3 was one of the early characteristics of tumors.
1999, 26(6): 437-438.
Abstract：
Objective To study the clinical and pathological feature of colorectal adenoma with canceration. Methods A study of 185 senile patients with collorectal adenoma was undertaken.The relation between colorectal adenoma and its malignant potential was observed. Results The malignant potential of elderly colorectal adenoma is associated with the factors of the site,shape,number of adenoma,histolocal type and age.There was no relationship between sex and canceration. Conclusion It is easily cancerative in elderly colorectal adenoma.The whole tumor should be removed in suspicious malignant adenoma.Close and regular follow-up should be done after recection.
Objective To study the clinical and pathological feature of colorectal adenoma with canceration. Methods A study of 185 senile patients with collorectal adenoma was undertaken.The relation between colorectal adenoma and its malignant potential was observed. Results The malignant potential of elderly colorectal adenoma is associated with the factors of the site,shape,number of adenoma,histolocal type and age.There was no relationship between sex and canceration. Conclusion It is easily cancerative in elderly colorectal adenoma.The whole tumor should be removed in suspicious malignant adenoma.Close and regular follow-up should be done after recection.
1999, 26(6): 439-441.
Abstract：
Objective To evaluate the effects of different chemotherapeutic projects on malignant thymoma. Methods The retrospective study summarized the data of 15 cases of phase Ⅲ.Ⅳ malignant thymoma from 1978 to Dec.1997. Results There was 0/7 RR in the group with cisplatin, the MTS were 9.5 months,while 3/8 RR in the other group without cisplatin,the MTS was 14 months;and the overall response rate was 20%,while the MTS was 14 months.There is statistical difference in rsponse between the two groups (P<0.05). Conclusion The chemotherapy with cisplatin did not get better of the chemotherapy without cisplatin in comparison of effect and survival time.
Objective To evaluate the effects of different chemotherapeutic projects on malignant thymoma. Methods The retrospective study summarized the data of 15 cases of phase Ⅲ.Ⅳ malignant thymoma from 1978 to Dec.1997. Results There was 0/7 RR in the group with cisplatin, the MTS were 9.5 months,while 3/8 RR in the other group without cisplatin,the MTS was 14 months;and the overall response rate was 20%,while the MTS was 14 months.There is statistical difference in rsponse between the two groups (P<0.05). Conclusion The chemotherapy with cisplatin did not get better of the chemotherapy without cisplatin in comparison of effect and survival time.
1999, 26(6): 442-443.
Abstract：
Objective To study of reurrent diagnosis and the indications surgical cancer after curative radiotherapeatics. Methods The 48 cases of esophagram was esophgostenosis and esophageal stiff in the 21 patients,The esophaguses filling defect with a little of multiple niches in the 25 patients,The 2 cases was a large of esophageal ulcer and esophagetopy.The 48 cases recurrent esophageal carcinomas after curative rediotherapy on operating in the meantime was the five weeks and the 48 months. Results In the 48 cases a radical esophagectomy the 46 patents,The overall resectability was 95.8%,and on after of the complication was 9.2%.The one postoperative deaths due to pulmonary of the complication,The operative mortality was 2.9%.The 1、3、5 years survival rates were 84.4%(38/45)、35.6%(16/45)、24.4%(11/45) respectively. Conclusion In the mean 6～10 the months of recurrent esophageal carcinomas after curative rediotherapy.The five of the weeks with the six months was sargical operatived the best time,on the recurrence esophageal carcinomas after curatived rediotherapy.But on the esophagography was a large of esophageal ulcer and esophagetopy,and the lymphaden were metastasis of a carcinoma,It the must dismissd from operatived treatment.
Objective To study of reurrent diagnosis and the indications surgical cancer after curative radiotherapeatics. Methods The 48 cases of esophagram was esophgostenosis and esophageal stiff in the 21 patients,The esophaguses filling defect with a little of multiple niches in the 25 patients,The 2 cases was a large of esophageal ulcer and esophagetopy.The 48 cases recurrent esophageal carcinomas after curative rediotherapy on operating in the meantime was the five weeks and the 48 months. Results In the 48 cases a radical esophagectomy the 46 patents,The overall resectability was 95.8%,and on after of the complication was 9.2%.The one postoperative deaths due to pulmonary of the complication,The operative mortality was 2.9%.The 1、3、5 years survival rates were 84.4%(38/45)、35.6%(16/45)、24.4%(11/45) respectively. Conclusion In the mean 6～10 the months of recurrent esophageal carcinomas after curative rediotherapy.The five of the weeks with the six months was sargical operatived the best time,on the recurrence esophageal carcinomas after curatived rediotherapy.But on the esophagography was a large of esophageal ulcer and esophagetopy,and the lymphaden were metastasis of a carcinoma,It the must dismissd from operatived treatment.
1999, 26(6): 444-446.
Abstract：
Objective To improve the diagnostic level and surgical curative effect of the intracranial cholesteatoma. Methods Analyse and summarize the clinical materials included the clinical main manifestations,diagnostic modes,microsurgical approach,and outcome of 218 patients with the intracranial cholesteatoma. Results There were 203 cases(93.1%)total removal of the tumor.In the remaining 15 patients(6.9%),adhesion tightly to the thalamus or brain stem made only subtotal removal of the capsule of tumor. 5 patients were died(2.3%)because of brain stem ischemia or edema,and lung infection within two weeks postoperatively.Long-term follow-up review(mean 5.6 years)in 176 patients revealed good recovery of 170 patients(96.6%),contrasted with a 1.7%(3 cases)late recurrence rate after operations.This patients with recurrence of tumor need to treat by again operative management. Conclusion It is effective method by using the CT or MRI to diagnose and microsurgical technique to remove cholesteatoma for these patients.
Objective To improve the diagnostic level and surgical curative effect of the intracranial cholesteatoma. Methods Analyse and summarize the clinical materials included the clinical main manifestations,diagnostic modes,microsurgical approach,and outcome of 218 patients with the intracranial cholesteatoma. Results There were 203 cases(93.1%)total removal of the tumor.In the remaining 15 patients(6.9%),adhesion tightly to the thalamus or brain stem made only subtotal removal of the capsule of tumor. 5 patients were died(2.3%)because of brain stem ischemia or edema,and lung infection within two weeks postoperatively.Long-term follow-up review(mean 5.6 years)in 176 patients revealed good recovery of 170 patients(96.6%),contrasted with a 1.7%(3 cases)late recurrence rate after operations.This patients with recurrence of tumor need to treat by again operative management. Conclusion It is effective method by using the CT or MRI to diagnose and microsurgical technique to remove cholesteatoma for these patients.
1999, 26(6): 447-448.
Abstract：
Immunohistochemistry detection of P16 expression was carried out in 41 cases of renal carcinoma,in 18 normal renal tissue adjacent to neoplastic lesions and in 10 normal renal tissue.The positive rates of P16 was higher in normal renal tissue(89.3%)than in tumor tissue(58.5%)(P<0.05),and correlated with grading、staging and prognosis of patients,with no significant difference between clear renal cell carcinoma and granular cell carcinona.The results suggested that P16 played a critical role in the genesis and development of RCC and could be used as predictor of diagnosis and prognosis of renal carcinoma.
Immunohistochemistry detection of P16 expression was carried out in 41 cases of renal carcinoma,in 18 normal renal tissue adjacent to neoplastic lesions and in 10 normal renal tissue.The positive rates of P16 was higher in normal renal tissue(89.3%)than in tumor tissue(58.5%)(P<0.05),and correlated with grading、staging and prognosis of patients,with no significant difference between clear renal cell carcinoma and granular cell carcinona.The results suggested that P16 played a critical role in the genesis and development of RCC and could be used as predictor of diagnosis and prognosis of renal carcinoma.
1999, 26(6): 449-450.
Abstract：
Objective To study the reason and mechanism of nonsecific antihypertensive effect after the operation of esophago-cardiac Cancer by hypertension. Methods Diastolic pressure(Dp) was higher than 14.7kpa or systolic pressare (SP) was higher than 24kpa thay reciped antihyperten sive Drugs before the operation or thay were intravanous dripped Nitrogly-Cerinum.during the operation for deliberate hypotension. Results There were 58 cases in this group after the operation.DP was lowered below 12.6kpa.SP was lowered 12%～18%.The effect were lowered in association with blood prassure of fore-operation. Conclusion The following four were reason and mechanism of non-specific antihypertensive effect after the operation of esophago-cardiac cancer by hypertensicn:①thay were done weay with stressor and stress resspones.②anemia lead to blood wiscosity lowered.③intrapulmonary-stomach stimulused aortic arch and heart lung baroreceptor so antihypertensive reflex increased.④the secrine of vasodilator matter increased and the secrine of vasoconstrictor matter decrased.
Objective To study the reason and mechanism of nonsecific antihypertensive effect after the operation of esophago-cardiac Cancer by hypertension. Methods Diastolic pressure(Dp) was higher than 14.7kpa or systolic pressare (SP) was higher than 24kpa thay reciped antihyperten sive Drugs before the operation or thay were intravanous dripped Nitrogly-Cerinum.during the operation for deliberate hypotension. Results There were 58 cases in this group after the operation.DP was lowered below 12.6kpa.SP was lowered 12%～18%.The effect were lowered in association with blood prassure of fore-operation. Conclusion The following four were reason and mechanism of non-specific antihypertensive effect after the operation of esophago-cardiac cancer by hypertensicn:①thay were done weay with stressor and stress resspones.②anemia lead to blood wiscosity lowered.③intrapulmonary-stomach stimulused aortic arch and heart lung baroreceptor so antihypertensive reflex increased.④the secrine of vasodilator matter increased and the secrine of vasoconstrictor matter decrased.
1999, 26(6): 451-452.
Abstract：
Objective To discuss the method for granisetron tablets in the prevention of acute vomiting induced by chemotherapy. Methods Forty-five patients with chemotherapy comprise cisplatin,adriamycin,and dacarbazine underwent anti-emetic therapy from November 1996 to July 1997.The chemotherapy regimens include CHOP, ABVD, CAP CAF,EPand FP.The dose of PDD was 70～80mg/M2,ADM was 40～50mg/M2 and DTIC was 300mg/M2.Granisetron 3mg p.o.at 3 hours before chemotherapy on the first day. Results The rates of complete control-free of vomiting were 64.4%,64.4%,71.1%,82.2% and 88.9% D1-5.The rates of overall control were 86.7%,88.9%,88.9%,91.1% and 93.3% D1-5. Conclusion Granisetron 3mg p.o.at 3 hours before chemotherapy on the first day is effective in the prevention on acute vomiting induced by chemotherapy.
Objective To discuss the method for granisetron tablets in the prevention of acute vomiting induced by chemotherapy. Methods Forty-five patients with chemotherapy comprise cisplatin,adriamycin,and dacarbazine underwent anti-emetic therapy from November 1996 to July 1997.The chemotherapy regimens include CHOP, ABVD, CAP CAF,EPand FP.The dose of PDD was 70～80mg/M2,ADM was 40～50mg/M2 and DTIC was 300mg/M2.Granisetron 3mg p.o.at 3 hours before chemotherapy on the first day. Results The rates of complete control-free of vomiting were 64.4%,64.4%,71.1%,82.2% and 88.9% D1-5.The rates of overall control were 86.7%,88.9%,88.9%,91.1% and 93.3% D1-5. Conclusion Granisetron 3mg p.o.at 3 hours before chemotherapy on the first day is effective in the prevention on acute vomiting induced by chemotherapy.
1999, 26(6): 453-454.
Abstract：
Objective To study the effect of abdominal paracentesis drip chemotherapy (APDC)before and after operation of advanced gastric and large interstine carcinoma (AGLIC) on preventing relapse and hepatometastasis as well as the practicablity of this method Methods One hundred and twenty seven patients with AGLIC were selected,and randomly divided into APDC'S(n=74) and vein chemotherapy's groups(n=53).The drugs,dosages and using period of the 2 groups were similar.The former were directly given the APDC before and after operations and the later done the peripheral vein chemotherapies after operations. Results After operations,there were significant difference in the rate of both the 2-year“non-tumor” survival and relapse metastasis between the 2 groups after operations(P<0.05).No chemtherapy's comlications developed in both the 2 groups. Conclusion The APDC before and after operation has abvious effect on preventing relapse and metastasis during the 2 years after the AGLIC operations,can effectively improve the existence quality,and is simple,safe and practical.
Objective To study the effect of abdominal paracentesis drip chemotherapy (APDC)before and after operation of advanced gastric and large interstine carcinoma (AGLIC) on preventing relapse and hepatometastasis as well as the practicablity of this method Methods One hundred and twenty seven patients with AGLIC were selected,and randomly divided into APDC'S(n=74) and vein chemotherapy's groups(n=53).The drugs,dosages and using period of the 2 groups were similar.The former were directly given the APDC before and after operations and the later done the peripheral vein chemotherapies after operations. Results After operations,there were significant difference in the rate of both the 2-year“non-tumor” survival and relapse metastasis between the 2 groups after operations(P<0.05).No chemtherapy's comlications developed in both the 2 groups. Conclusion The APDC before and after operation has abvious effect on preventing relapse and metastasis during the 2 years after the AGLIC operations,can effectively improve the existence quality,and is simple,safe and practical.
1999, 26(6): 455-456.
Abstract：
Objective To evaluate the diagnostic value of CT in the neoplasm of maxillary sinus. Methods The CT images of 38 cases with maxillary sinus neoplasm confirmed by surgery and pathology were retrospectively analyzed. Results 23 cases of maxillary sinus neoplasm were malignant,15 cases were benign The key points to diagnose and differentiate were that whether the shape of the mass was regular,the density of the mass was uniform and the change of maxillary bone was hypertrophy,expansive,remodeling or destructive.The fat around the maxillary sinus was infiltrated or not. Conclusion CT scanning is helpful to diagnose and differentiate the nature of maxillary sinus neoplasm,and provides important information for the clinicians to plan proper surgical treatment.
Objective To evaluate the diagnostic value of CT in the neoplasm of maxillary sinus. Methods The CT images of 38 cases with maxillary sinus neoplasm confirmed by surgery and pathology were retrospectively analyzed. Results 23 cases of maxillary sinus neoplasm were malignant,15 cases were benign The key points to diagnose and differentiate were that whether the shape of the mass was regular,the density of the mass was uniform and the change of maxillary bone was hypertrophy,expansive,remodeling or destructive.The fat around the maxillary sinus was infiltrated or not. Conclusion CT scanning is helpful to diagnose and differentiate the nature of maxillary sinus neoplasm,and provides important information for the clinicians to plan proper surgical treatment.
1999, 26(6): 457-458.
Abstract：
Objective The effects of treat the brain metastasis with radiotherapy along(R),radiotherapy plus chemotherapy (R+C) and stereotactic radiosurgery plus radiotherapy (SRS+R)were analysed retrospectively. Methods From May 1993 to June 1998,61 cases of brain metastasis were studied in 3 groups. Results The 6-,12-,>12-month survival rate and local control rate in group R as 54.1%,16.3%,2.7% and 16.2%,in group R+C as 75.0%,33.3%,25.0% and 41.6%,in gruop SRS+R as 83.3%,58.3%,41.6% and 91.6%. Conclusion SRS+R is superior than R+C and R in the prolong survile period and local control in treat the brain metastase.
Objective The effects of treat the brain metastasis with radiotherapy along(R),radiotherapy plus chemotherapy (R+C) and stereotactic radiosurgery plus radiotherapy (SRS+R)were analysed retrospectively. Methods From May 1993 to June 1998,61 cases of brain metastasis were studied in 3 groups. Results The 6-,12-,>12-month survival rate and local control rate in group R as 54.1%,16.3%,2.7% and 16.2%,in group R+C as 75.0%,33.3%,25.0% and 41.6%,in gruop SRS+R as 83.3%,58.3%,41.6% and 91.6%. Conclusion SRS+R is superior than R+C and R in the prolong survile period and local control in treat the brain metastase.
1999, 26(6): 459-462.
Abstract：
Objective analysis of 612 patients with nasopharyngeal carcinoma(NPC)treated by radiotherapy from January,1973 to December,1987 was done.The overall 5-year survival rate was 42.2%.Analysis showed that tumor stage,extra-cavitary extension,cervical node metastasis,cranial nerve involvement and dosage were the main signifi-cant prognostic factors.Gradual decrease of 5-year survival rate was seen from stage Ⅰ to Ⅳ,The 5-year survival rate was higher in patients with the tumor limited in nasopharynx than those with tumor extending out of nasopharynx(P＜0.01).The invasion of both anterior and posterior cranial never groups was the poorest.The size,region(ipsilateral of bilateral and upper or lower neck)and movability of the metastatic nodes could influence therapeutic results on NPC.The radiation dose ranged from 65-75Gy/6.5-7.5W.Distant metastasis and local recurrence were the main causes of treatment failure.
Objective analysis of 612 patients with nasopharyngeal carcinoma(NPC)treated by radiotherapy from January,1973 to December,1987 was done.The overall 5-year survival rate was 42.2%.Analysis showed that tumor stage,extra-cavitary extension,cervical node metastasis,cranial nerve involvement and dosage were the main signifi-cant prognostic factors.Gradual decrease of 5-year survival rate was seen from stage Ⅰ to Ⅳ,The 5-year survival rate was higher in patients with the tumor limited in nasopharynx than those with tumor extending out of nasopharynx(P＜0.01).The invasion of both anterior and posterior cranial never groups was the poorest.The size,region(ipsilateral of bilateral and upper or lower neck)and movability of the metastatic nodes could influence therapeutic results on NPC.The radiation dose ranged from 65-75Gy/6.5-7.5W.Distant metastasis and local recurrence were the main causes of treatment failure.
1999, 26(6): 461-462.
Abstract：
23 Cases with cancer of head of pancreas were treated in our hospital from 1980～1992.All cases were explored by laporotomy and the diagnosis of all cases were comfirmed by histopathology.Of 23 cases,pancreatoduodenectomy was performed in six cases,local resection in one case,the resectable rate was 30.4%,the lower resectable rate was due to advanced stage in the most of patients.In the non-resection group,the average survival time was 5.2 months,the one year survival rate was 18.8%.The clinical characteristics, the value of diagnosis of ultrosonic wave and CT,how to raise the positive rate of pathology and the resection rate were discussed in this article.
23 Cases with cancer of head of pancreas were treated in our hospital from 1980～1992.All cases were explored by laporotomy and the diagnosis of all cases were comfirmed by histopathology.Of 23 cases,pancreatoduodenectomy was performed in six cases,local resection in one case,the resectable rate was 30.4%,the lower resectable rate was due to advanced stage in the most of patients.In the non-resection group,the average survival time was 5.2 months,the one year survival rate was 18.8%.The clinical characteristics, the value of diagnosis of ultrosonic wave and CT,how to raise the positive rate of pathology and the resection rate were discussed in this article.
1999, 26(6): 463-464.
Abstract：
Objective To evaluate the value of CT and MRI in the diagnosis of intracranial lipoma. Methods 10 cases of intracr anial lipoma were analyzed in comparing their CT and MRI manifestations with their operating pathology. Results Tumors are located in corpus callosum in 8 cases,in third ventricle of cerebrum in 1 and in lateral sulcus in 1.3 cases of lipoma in corpus callosum are accompanied by lipomas in choroid plexus of bilateral ventricles,rarely.Their CT manifestations are even low density area in 7 cases,not even in 3 and calcified tumors in 3.Tumors in 3 cases examined with MRI are high intensive signal in T1WⅠ and T2WⅠ. Conclusion :Lipomas may be diagnosed with CT manifestations as different-shape low density area in corpus callosum,negative CT value or accompanying tumor calcified,and MRI manifestations as high intensive signal in T1WⅠ and T2WⅠ.
Objective To evaluate the value of CT and MRI in the diagnosis of intracranial lipoma. Methods 10 cases of intracr anial lipoma were analyzed in comparing their CT and MRI manifestations with their operating pathology. Results Tumors are located in corpus callosum in 8 cases,in third ventricle of cerebrum in 1 and in lateral sulcus in 1.3 cases of lipoma in corpus callosum are accompanied by lipomas in choroid plexus of bilateral ventricles,rarely.Their CT manifestations are even low density area in 7 cases,not even in 3 and calcified tumors in 3.Tumors in 3 cases examined with MRI are high intensive signal in T1WⅠ and T2WⅠ. Conclusion :Lipomas may be diagnosed with CT manifestations as different-shape low density area in corpus callosum,negative CT value or accompanying tumor calcified,and MRI manifestations as high intensive signal in T1WⅠ and T2WⅠ.
1999, 26(6): 465-466.
Abstract：
Objective To investigat the mode of cell death after irradiation in one human lung adenocarcinoma cell line and a human normal lung fibroblast cell line. Methods The morphology of dead cells and dou-ble strands break in apoptotic cells were observed by HE stain and comet assay.The variety of cell cycle and emerging time of apoptosis after irradiation were examined by flow cytometry analysis. Results Apoptotic cells emerged in the lung adenocarcinoma cells after irradiation and appeared in G1 arrest subsequent to overcoming G2 arrest after irradiation.Only was necrosis observed in the fibroblast cells. Conclusion Apoptosis is one of the ultimate forms of cell death via mitotic failure caused by irradiation in lung adenocarcinoma cells.The advent of mitotic apoptosis depended on the radiation doses and incubation time. The fact that mitotic mecrosis might be the major cause of fibroblast death demonstrated that mitotic death modes were complex and various in different lines.
Objective To investigat the mode of cell death after irradiation in one human lung adenocarcinoma cell line and a human normal lung fibroblast cell line. Methods The morphology of dead cells and dou-ble strands break in apoptotic cells were observed by HE stain and comet assay.The variety of cell cycle and emerging time of apoptosis after irradiation were examined by flow cytometry analysis. Results Apoptotic cells emerged in the lung adenocarcinoma cells after irradiation and appeared in G1 arrest subsequent to overcoming G2 arrest after irradiation.Only was necrosis observed in the fibroblast cells. Conclusion Apoptosis is one of the ultimate forms of cell death via mitotic failure caused by irradiation in lung adenocarcinoma cells.The advent of mitotic apoptosis depended on the radiation doses and incubation time. The fact that mitotic mecrosis might be the major cause of fibroblast death demonstrated that mitotic death modes were complex and various in different lines.
1999, 26(6): 467-468.
Abstract：
Objective From 1986 to 1993,102 mouth cavity caricinoma patients were treatecl by radiotnerapy,of them,51 were given irregular tractionated irradiation.They received 6Gy(A)→1.2Gy(B)→1.2Gy(A)→1.2GY(B)→1.2GY(A).After a rest of two days,the above cgcle was repeated.The total dose given was 64.8Gy/6W(10.8Gy/W×6).51 patients treated by conventional fractionation irradiation.The total dose given was 66Gy/6.5W(10Gy/W×6.5). Results :The improvement rate of short-term carative effect was 96.1% in the irregular tructionation irradiation graup,and 74.5% in thd conventional fraup Five-Year survival rate was 43.1% in the irregular tractionation irrodeation group,and 21.6% in the conventional one,with a remarkably difference between them(P＜0.05)
Objective From 1986 to 1993,102 mouth cavity caricinoma patients were treatecl by radiotnerapy,of them,51 were given irregular tractionated irradiation.They received 6Gy(A)→1.2Gy(B)→1.2Gy(A)→1.2GY(B)→1.2GY(A).After a rest of two days,the above cgcle was repeated.The total dose given was 64.8Gy/6W(10.8Gy/W×6).51 patients treated by conventional fractionation irradiation.The total dose given was 66Gy/6.5W(10Gy/W×6.5). Results :The improvement rate of short-term carative effect was 96.1% in the irregular tructionation irradiation graup,and 74.5% in thd conventional fraup Five-Year survival rate was 43.1% in the irregular tractionation irrodeation group,and 21.6% in the conventional one,with a remarkably difference between them(P＜0.05)
