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摘要:
卵巢癌发病率居女性恶性肿瘤第三位，死亡率居首位，且预后较差，对女性生命健康造成严重威胁，其发病及预后与遗传、内分泌失调以及不良生活方式等因素有关。近年来，有学者开展了生活方式，特别是轮班工作与卵巢癌发生及发展关系的研究。轮班工作会导致昼夜节律紊乱，影响体内的激素平衡，可能是卵巢癌的危险因素。本综述归纳了轮班工作与卵巢癌关系的4项队列研究和2项病例对照研究，但研究结论尚不一致，其与卵巢癌的关系仍需进一步探索。
Abstract:The incidence rate of ovarian cancer ranks the third among female malignant tumors, the mortality rate ranks the first and the prognosis is poor. Ovarian cancer poses a serious threat to the health of women's lives. The incidence of ovarian cancer is related to heredity, endocrine disorders and adverse lifestyle factors. In recent years, some scholars have carried out the impact of lifestyle, especially shift work, on the occurrence and development of ovarian cancer. Shift work can lead to circadian disruption, which affects hormonal balance in the body and may be a risk factor for ovarian cancer. This review summarizes four cohort studies and two case-control studies on the relation between shift work and ovarian cancer. The conclusion of the studies is inconsistent, suggesting that further researches are needed.
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Key words:
- Ovarian cancer /
- Shift work /
- Mechanism
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Competing interests: The authors declare that they have no competing interests.作者贡献高畅：检查并筛选文献、对纳入文献进行定性分析、撰写论文张爽、闻赵燕：文献检索及对纳入文献进行定性分析宫婷婷、赵玉虹：选题和论文修改吴琪俊：选题、论文修改及终审
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表 1 轮班工作与卵巢癌关系的研究信息
Table 1 Researches about relation between shift work and ovarian cancer
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