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摘要:
经典Wnt信号通路受体抑制剂由分泌型卷曲相关蛋白家族（secreted frizzled related proteins, SFRPs）和DKK家族（the Dickkopf family, Dkk）构成。SFRPs通过将Wnt与活性受体复合物分离而抑制Wnt/β-catenin信号。SFRPs启动子超甲基化表观遗传沉默似乎发生在所有类型肿瘤进展中。作为Wnt信号转导通路抑制剂，SFRPs与女性恶性肿瘤的病理进展及预后密切相关。为了攻坚其靶向治疗难题，深入研究SFRPs影响女性恶性肿瘤机理具有重要的意义。本文就Wnt信号通路及其重要拮抗剂SFRPs家族在女性恶性肿瘤中的作用进行简要综述。
Abstract:The classical Wnt signaling pathway receptor inhibitors are composed of secreted frizzled-related proteins (SFRPs) and the Dickkopf family (Dkk). SFRPs inhibit wnt/β-catenin signaling by sequestering Wnt from the active receptor complexes. In tumor progression, epigenetic silencing of SFRPs promoter by hypermethylation seems to occur in all tumor types. SFRPs are closely related with the pathological progress and prognosis of female malignant tumor. In order to solve the problem of targeted therapy, it is of great significance to study the mechanism of SFRPs for female malignant tumors. In this paper, we review the research progress of Wnt signaling pathway and important antagonist SFRPs family in female malignant tumor.
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作者贡献张丽轩：确定选题，收集资料，起草及修改文章刘朝奇：整理文献，指导论文李志英：提出选题，指导论文
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