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摘要:
睾丸核蛋白中线癌是一种具有高度侵袭性的恶性上皮肿瘤。该肿瘤主要以15q14上的NUT基因发生染色体重排，使NUT蛋白在睾丸外表达为特征。病理上，该肿瘤是一种伴有局灶性鳞状分化的未分化癌。NUT中线癌可发生于全身多个部位，以头颈部中线结构和纵隔多见，肺源性病例罕见且少有记录。但是，肺源性NUT中线癌的临床病程异常迅速、凶险，且诊断特点尚不明确。因此，本文主要探讨了关于原发性肺NUT中线癌的临床诊断和治疗方法。
Abstract:The nuclear protein of the testis (NUT) midline carcinoma is a highly aggressive malignant epithelial neoplasm. The tumor is characterized by chromosome rearrangement of the NUT gene on 15q14, which results in the expression of NUT protein outside the testis. Pathologically, the tumor is an undifferentiated carcinoma with focal squamous differentiation. The NUT midline carcinoma can occur in multiple parts of the body, most of which happen in the midline structure of the head and neck and the mediastinum. Pulmonary cases are unusual and rarely recorded. However, the clinical course of primary lung NUT midline carcinoma is abnormally rapid and dangerous, and the diagnostic characteristics are still unclear. Therefore, this paper mainly discusses the clinical diagnosis and treatment of primary lung NUT midline carcinoma.
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Key words:
- Lung /
- NUT midline carcinoma /
- Bromodomain-containing protein(BRD4)
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