Efficacy and Prognostic Factors of Docetaxel Combined with ADT on Metastatic Hormone-sensitive Prostate Cancer Patients
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摘要:目的
评价多西他赛联合雄激素剥夺疗法(ADT)治疗转移性去势敏感性前列腺癌(mHSPC)患者的疗效,并分析其预后影响因素。
方法回顾性分析107例mHSPC患者的临床资料,所有患者均行多西他赛联合ADT治疗,观察终点为前列腺特异性抗原无进展生存期(PSA PFS)和影像学无进展生存期(rPFS)。采用Cox单因素和多因素回归分析患者PSA PFS和rPFS的相关预后影响因素。
结果中位随访时间36月,13例患者死亡。中位PSA PFS 34.000(30.878~37.122)月,中位rPFS 33.000(30.031~35.969)月。单因素回归分析显示:初始血清PSA值、治疗7月时PSA最低值是否低于0.2 ng/dl、化疗周期数、患者体能状态评分(ECOG)、是否伴有内脏转移与患者的PSA FPS、rPFS显著相关。多因素回归分析显示:治疗7月时PSA最低值是否低于0.2 ng/dl以及是否伴有内脏转移与患者的PSA FPS、rPFS显著相关。
结论多西他赛联合ADT治疗中国mHSPC患者疗效较好,治疗7月时PSA最低值是否低于0.2 ng/dl以及是否伴有内脏转移是患者PSA FPS、rPFS的独立预后因素。
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关键词:
- 多西他赛 /
- 雄激素剥夺疗法 /
- 转移性去势敏感性前列腺癌 /
- 疗效 /
- 预后因素
Abstract:ObjectiveTo assess the efficacy of docetaxel plus ADT on mHSPC patients and analyze the prognostic factors.
MethodsWe retrospectively reviewed the clinical data of 107 mHSPC patients treated with docetaxel plus ADT. Co-primary end points were PSA PFS and rPFS. Univariable and multivariable Cox analyses were performed to determine prognostic factors for PSA PFS and rPFS.
ResultsThe median follow-up time was 36 months, and 13 (12.1%) patients died. The median PSA PFS and rPFS were 34.000 (30.878-37.122) and 33.000 (30.031-35.969) months, respectively. Univariate analysis results showed that the serum PSA, PSA nadir at 7th month (≤0.2ng/dl vs. > 0.2ng/dl), number of chemotherapy cycles (≤6 vs. 7-12), ECOG PS (0-1 vs. 2) and visceral disease (yes vs. no) were independent predictors for PSA PFS and rPFS. Multivariate analysis results showed that PSA nadir at 7th month (≤0.2ng/dl vs. > 0.2ng/dl) and visceral disease (yes vs. no) were independent predictors for PSA PFS and rPFS.
ConclusionThe effect of docetaxel plus ADT on patients with mHSPC in China is favorable. PSA nadir at 7th month (≤0.2ng/dl vs. > 0.2ng/dl) and visceral disease (yes vs. no) are independent predictors for PSA PFS and rPFS.
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Key words:
- Docetaxel /
- ADT /
- Metastatic hormone-sensitive prostate cancer /
- Efficacy /
- Prognostic factor
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作者贡献刘三河:论文撰写崔殿生:论文设计贾全安:病例收集段丽群:统计分析邓康俐:统计指导黄雷:方案实施魏少忠:论文指导
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表 1 107例mHSPC患者的基本情况((n)%)
Table 1 Clinical characteristic of 107 mHSPC patients ((n)%)
表 2 多西他赛联合ADT治疗mHSPC患者预后的单因素分析
Table 2 Univariate analysis of clinical parameters of mHSPC patients treated with docetaxel combined with ADT
表 3 多西他赛联合ADT治疗mHSPC患者预后的多因素分析
Table 3 Multivariate analysis of clinical parameters of mHSPC patients treated with docetaxel combined with ADT
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