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藻蓝蛋白抗肿瘤的应用现状

刘慧慧, 姜良乾, 王玉娟, 刘国祥, 姬欢欢, 任俊逸, 李冰

刘慧慧, 姜良乾, 王玉娟, 刘国祥, 姬欢欢, 任俊逸, 李冰. 藻蓝蛋白抗肿瘤的应用现状[J]. 肿瘤防治研究, 2018, 45(6): 420-424. DOI: 10.3971/j.issn.1000-8578.2018.17.1464
引用本文: 刘慧慧, 姜良乾, 王玉娟, 刘国祥, 姬欢欢, 任俊逸, 李冰. 藻蓝蛋白抗肿瘤的应用现状[J]. 肿瘤防治研究, 2018, 45(6): 420-424. DOI: 10.3971/j.issn.1000-8578.2018.17.1464
LIU Huihui, JIANG Liangqian, WANG Yujuan, LIU Guoxiang, JI Huanhuan, REN Junyi, LI Bing. Application Status of C-phycocyanin in Anti-tumor[J]. Cancer Research on Prevention and Treatment, 2018, 45(6): 420-424. DOI: 10.3971/j.issn.1000-8578.2018.17.1464
Citation: LIU Huihui, JIANG Liangqian, WANG Yujuan, LIU Guoxiang, JI Huanhuan, REN Junyi, LI Bing. Application Status of C-phycocyanin in Anti-tumor[J]. Cancer Research on Prevention and Treatment, 2018, 45(6): 420-424. DOI: 10.3971/j.issn.1000-8578.2018.17.1464

藻蓝蛋白抗肿瘤的应用现状

基金项目: 

国家自然科学基金 81471546

国家自然科学基金 81001346

国家自然科学基金 81273206

详细信息
    作者简介:

    刘慧慧(1991-),女,硕士,主要从事肿瘤靶向治疗研究

    通信作者:

    李冰,E-mail: libing_516619@163.com

  • 中图分类号: R73-36

Application Status of C-phycocyanin in Anti-tumor

More Information
  • 摘要:

    近年来,在海洋生物中寻找高效、低毒、不良反应小的抗肿瘤药物已引起了国内外学者的重视。藻蓝蛋白(C-phycocyanin, C-PC)对多种肿瘤细胞具有毒副作用,可以抑制肿瘤细胞的生长,促进肿瘤细胞的凋亡。联合其他药物可以提高藻蓝蛋白的抗肿瘤活性。现对藻蓝蛋白抗肿瘤作用的研究进展进行总结,为新型天然药物的研发提供依据。

     

    Abstract:

    In recent years, the search for anti-tumor drugs with high efficiency, low toxicity and little side effects in marine organisms has attracted the attention of scholars. C-phycocyanin (C-PC) has toxic and side effects on a variety of tumor cells, which can inhibit the growth of tumor cells and promote the apoptosis of tumor cells. Phycocyanin combined with other drugs can improve its anti-tumor activity. This review discusses the therapeutic use of phycocyanin and focuses on the latest advances of phycocyanin as a promising natural anti-cancer drug.

     

  • [1]

    Jung IL. Soluble extract from Moringa oleifera leaves with a new anticancer activity[J]. PLoS One, 2014, 9(4): e95492. doi: 10.1371/journal.pone.0095492

    [2]

    Madamwar D, Patel DK, Desai SN, et al. Apoptotic potential of C-phycoerythrin from Phormidium sp. A27DM and Halomicronema sp. A32DM on human lung carcinoma cells[J]. EXCLI J, 2015, 14: 527-39. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614113/

    [3]

    Rastogi RP, Sonani RR, Madamwar D. Effects of PAR and UV Radiation on the Structural and Functional Integrity of Phycocyanin, Phycoerythrin and Allophycocyanin Isolated from the Marine Cyanobacterium Lyngbya sp. A09DM[J]. Photochem Photobiol, 2015, 91(4): 837-44. doi: 10.1111/php.2015.91.issue-4

    [4]

    Chen Z, Zhan J, Chen Y, et al. Effects of Phosphorylation of beta Subunits of Phycocyanins on State Transition in the Model Cyanobacterium Synechocystis sp. PCC 6803[J]. Plant Cell Physiol, 2015, 56(10): 1997-2013. doi: 10.1093/pcp/pcv118

    [5]

    de Jesus Raposo MF, de Morais RM, de Morais AM. Health applications of bioactive compounds from marine microalgae[J]. Life Sci, 2013, 93(15): 479-86. doi: 10.1016/j.lfs.2013.08.002

    [6]

    Kissoudi M, Sarakatsianos I, Samanidou V. Isolation and purification of food-grade C-phycocyanin from Arthrospira platensis and its determination in confectionery by HPLC with Diode Array Detection[J]. J Sep Sci, 2017. [Epub ahead of print]

    [7] 张军, 邹宁, 孙东红, 等.螺旋藻抗肿瘤组分的研究进展[J].食品研究与开发, 2016, 37(14): 214-6. doi: 10.3969/j.issn.1005-6521.2016.14.052

    Zhang J, Zou N, Sun DH, et al. A Summary of the Document on Anticancer Activity of Spirulina Component[J]. Shi Pin Yan Jiu Yu Kai Fa, 2016, 37(14): 214-6. doi: 10.3969/j.issn.1005-6521.2016.14.052

    [8]

    Stadnichuk IN, Krasil'nikov PM, Zlenko DV. Cyanobacterial Phycobilisomes and Phycobiliproteins[J]. Mikrobiologiia, 2015, 84(2): 131-43. http://www.ncbi.nlm.nih.gov/pubmed/26263619/

    [9]

    Adir N, Lerner N. The crystal structure of a novel unmethylated form of C-phycocyanin, a possible connector between cores and rods in pycobilisomes[J]. J Biol Chem, 2003, 278(28): 25926-32. doi: 10.1074/jbc.M302838200

    [10]

    Ravi M, Tentu S, Baskar G, et al. Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells[J]. BMC Cancer, 2015, 15: 768. doi: 10.1186/s12885-015-1784-x

    [11]

    Bechelli J, Coppage M, Rosell K, et al. Cytotoxicity of algae extracts on normal and malignant cells[J]. Leuk Res Treatment, 2011, 2011: 373519. https://www.hindawi.com/journals/lrt/2011/373519/fig3/

    [12]

    Pleonsil P, Soogarun S, Suwanwong Y. Anti-oxidant activity of holo- and apo-c-phycocyanin and their protective effects on human erythrocytes[J]. Int J Biol Macromol, 2013, 60: 393-8. doi: 10.1016/j.ijbiomac.2013.06.016

    [13]

    Thangam R, Suresh V, Asenath Princy W, et al. C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest [J]. Food Chem, 2013, 140(1-2): 262-72. doi: 10.1016/j.foodchem.2013.02.060

    [14] 夏冬, 孙军燕, 刘娜娜, 等.藻蓝蛋白抗氧化作用及其药理活性研究进展[J].海洋科学, 2015, 39(7): 130-5. doi: 10.11759/hykx20140704001

    Xia D, Sun JY, Liu NN, et al. Research progress of the antioxidant activity of Phycocyanin and its application[J]. Hai Yang Ke Xue, 2015, 39(7): 130-5. doi: 10.11759/hykx20140704001

    [15]

    Zhu C, Ling Q, Cai Z, et al. Selenium-Containing Phycocyanin from Se-Enriched Spirulina platensis Reduces Inflammation in Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB Activation[J]. J Agric Food Chem, 2016, 64(24): 5060-70. doi: 10.1021/acs.jafc.6b01308

    [16]

    Shen G, Schluchter WM, Bryant DA. Biogenesis of phycobiliproteins: Ⅰ. cpcS-Ⅰ and cpcU mutants of the cyanobacterium Synechococcus sp. PCC 7002 define a heterodimeric phyococyanobilin lyase specific for beta-phycocyanin and allophycocyanin subunits[J]. J Biol Chem, 2008, 283(12): 7503-12. doi: 10.1074/jbc.M708164200

    [17]

    Niu YJ, Zhou W, Guo J, et al. C-Phycocyanin protects against mitochondrial dysfunction and oxidative stress in parthenogenetic porcine embryos[J]. Sci Rep, 2017, 7(1): 16992. doi: 10.1038/s41598-017-17287-0

    [18]

    Rimbau V, Camins A, Romay C, et al. Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus[J]. Neurosci Lett, 1999, 276(2): 75-8. doi: 10.1016/S0304-3940(99)00792-2

    [19]

    Rimbau V, Camins A, Pubill D, et al. C-phycocyanin protects cerebellar granule cells from low potassium/serum deprivation-induced apoptosis[J]. Naunyn Schmiedeberg's Arch Pharmacol, 2001, 364(2): 96-104. doi: 10.1007/s002100100437

    [20]

    Pattarayan D, Rajarajan D, Ayyanar S, et al. C-phycocyanin suppresses transforming growth factor-beta1-induced epithelial mesenchymal transition in human epithelial cells[J]. Pharmacol Rep, 2017, 69(3): 426-31. doi: 10.1016/j.pharep.2016.12.013

    [21]

    Wang CY, Wang X, Wang Y, et al. Photosensitization of phycocyanin extracted from Microcystis in human hepatocellular carcinoma cells: implication of mitochondria-dependent apoptosis[J]. J Photochem Photobiol B, 2012, 117: 70-9. doi: 10.1016/j.jphotobiol.2012.09.001

    [22]

    Li B, Chu X, Gao M, et al. Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin[J]. Acta Biochim Biophys Sin(Shanghai), 2010, 42(1): 80-9. http://www.ncbi.nlm.nih.gov/pubmed/20043050

    [23]

    Chang CJ, Yang YH, Liang YC, et al. A novel phycobiliprotein alleviates allergic airway inflammation by modulating immune responses[J]. Am J Respir Crit Care Med, 2011, 183(1): 15-25. doi: 10.1164/rccm.201001-0009OC

    [24]

    Nemoto-Kawamura C, Hirahashi T, Nagai T, et al. Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticles[J]. J Nutr Sci Vitaminol(Tokyo), 2004, 50(2): 129-36. doi: 10.3177/jnsv.50.129

    [25]

    Marín-Prida J, Pavón-Fuentes N, Llópiz-Arzuaga A, et al. Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats[J]. Toxicol Appl Pharmacol, 2013, 272(1): 49-60. doi: 10.1016/j.taap.2013.05.021

    [26]

    Iijma T, Saitoh N, Nobutomo K, et al. A prospective cohort study of hepatitis B surface antigen carriers in a working population[J]. Gan, 1984, 75(7): 571-3.

    [27]

    Kunte M, Desai K. The Inhibitory Effect of C-phycocyanin Containing Protein Extract (C-PC Extract) on Human Matrix Metalloproteinases (MMP-2 and MMP-9) in Hepatocellular Cancer Cell Line (HepG2)[J]. Protein J, 2017, 36(3): 186-95. doi: 10.1007/s10930-017-9707-0

    [28]

    Ying J, Wang J, Ji H, et al. Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation[J]. Gene, 2016, 585(1): 58-64. doi: 10.1016/j.gene.2016.03.023

    [29]

    Liao G, Gao B, Gao Y, et al. Phycocyanin Inhibits Tumorigenic Potential of Pancreatic Cancer Cells: Role of Apoptosis and Autophagy[J]. Sci Rep, 2016, 6: 34564. doi: 10.1038/srep34564

    [30] 应俊, 潘若望, 王茂峰, 等.藻蓝蛋白诱导喉癌HEP-2细胞凋亡的实验研究[J].中国病理生理杂志, 2015, 31(7): 1189-96. https://www.wenkuxiazai.com/doc/f16feaf50912a216147929d3.html

    Ying J, Pan RW, Wang MF, et al. Effects of phycocyanin on apoptosis of human laryngeal cancer HEP-2 cells[J]. Zhongguo Bing Li Sheng Li Za Zhi, 2015, 31(7): 1189-96. https://www.wenkuxiazai.com/doc/f16feaf50912a216147929d3.html

    [31] 李冰, 张学成, 高美华, 等.藻蓝蛋白对HeLa细胞CD59基因表达调控作用的研究[J].高技术通讯, 2006, 16(2): 196-200. https://www.wenkuxiazai.com/doc/71d592305a8102d276a22fb3.html

    Li B, Zhang XC, Gao MH, et al. Study of regulatory effect of phycocyanin on CD59 gene expression of HeLa cells[J]. Gao Ji Shu Tong Xun, 2006, 16(2): 196-200. https://www.wenkuxiazai.com/doc/71d592305a8102d276a22fb3.html

    [32] 李冰, 褚现明, 高美华, 等.钝顶螺旋藻藻蓝蛋白诱导HeLa细胞凋亡的分子机制研究[J].中国药理学通报, 2009, 25(8): 1045-50. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_zgylxtb200908016

    Li B, Chu XM, Gao MH, et al. Study on the molecular mechanism of C-phycocyanin from Spirulina platensis induced apoptosis in HeLa cells[J]. Zhongguo Yao Li Xue Tong Bao, 2009, 25(8): 1045-50. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_zgylxtb200908016

    [33]

    Morcos NC, Berns M, Henry WL. Phycocyanin: laser activation, cytotoxic effects, and uptake in human atherosclerotic plaque[J]. Lasers Surg Med, 1988, 8(1): 10-7. doi: 10.1002/(ISSN)1096-9101

    [34]

    Bharathiraja S, Seo H, Manivasagan P, et al. In Vitro Photodynamic Effect of Phycocyanin against Breast Cancer Cells[J]. Molecules, 2016, 21(11): pii: E1470. doi: 10.3390/molecules21111470

    [35] 李冰, 褚现明, 高美华.藻蓝蛋白-光动力疗法治疗小鼠HeLa细胞瘤的免疫和凋亡机制研究[J].中国激光医学杂志, 2011, 20(1): 1-6. http://www.cnki.com.cn/Article/CJFDTOTAL-YAOL201103023.htm

    Li B, Chu XM, Gao MH. Treatment of HeLa Tumor in mice with C-phycocyanin Mediated Photodynamic Therapy and Its Immune Mechanism Underlying Apoptosis[J]. Zhongguo Ji Guang Yi Xue Za Zhi, 2011, 20(1): 1-6. http://www.cnki.com.cn/Article/CJFDTOTAL-YAOL201103023.htm

    [36]

    Sun DF, Gao ZH, Liu HP, et al. Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARbeta expression[J]. Cancer Lett, 2012, 319(2): 182-9. doi: 10.1016/j.canlet.2012.01.012

    [37]

    Siddikuzzaman, Grace VM. Inhibition of metastatic lung cancer in C57BL/6 mice by liposome encapsulated all trans retinoic acid (ATRA)[J]. Int Immunopharmacol, 2012, 14(4): 570-9. doi: 10.1016/j.intimp.2012.09.008

    [38] 李冰, 杨帆, 吕丛仪, 等.藻蓝蛋白协同全反式维甲酸影响人宫颈癌HeLa细胞的增殖和凋亡[J].中国肿瘤生物治疗杂志, 2014, 21(5): 516-20. doi: 10.3872/j.issn.1007-385X.2014.5.006

    Li B, Yang F, Lyu CY, et al. Effects of C-phycocyanin combined with all-trans retinoic acid on cervical cancer cells proliferation and apoptosis[J]. Zhongguo Zhong Liu Sheng Wu Zhi Liao Za Zhi, 2014, 21(5): 516-20. doi: 10.3872/j.issn.1007-385X.2014.5.006

    [39]

    Yang F, Li B, Chu XM, et al. Molecular mechanism of inhibitory effects of C-phycocyanin combined with all-trans-retinoic acid on the growth of HeLa cells in vitro[J]. Tumour Biol, 2014, 35(6): 5619-28. doi: 10.1007/s13277-014-1744-0

    [40]

    Li B, Gao MH, Chu XM, et al. The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo[J]. Eur J Pharmacol, 2015, 749: 107-14. doi: 10.1016/j.ejphar.2015.01.009

    [41]

    Gantar M, Dhandayuthapani S, Rathinavelu A. Phycocyanin induces apoptosis and enhances the effect of topotecan on prostate cell line LNCaP[J]. J Med Food, 2012, 15(12): 1091-5. doi: 10.1089/jmf.2012.0123

    [42]

    Saini MK, Vaiphei K, Sanyal SN. Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin[J]. Mol Cell Biochem, 2012, 361(1-2): 217-28. doi: 10.1007/s11010-011-1106-9

    [43]

    Bingula R, Dupuis C, Pichon C, et al. Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo[J]. J Oncol, 2016, 2016: 8162952. http://www.freepatentsonline.com/EP1765397B1.html

    [44]

    Khan M, Varadharaj S, Shobha JC, et al. C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes[J]. J Cardiovasc Pharmacol, 2006, 47(1): 9-20. doi: 10.1097/01.fjc.0000191520.48404.27

    [45]

    Li B, Zhang X, Gao M, et al. Effects of CD59 on antitumoral activities of phycocyanin from Spirulina platensis[J]. Biomed Pharmacother, 2005, 59(10): 551-60. doi: 10.1016/j.biopha.2005.06.012

    [46]

    Li B, Gao MH, Zhang XC, et al. Molecular immune mechanism of C-phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro[J]. Biotechnol Appl Biochem, 2006, 43(Pt 3): 155-64. http://www.ncbi.nlm.nih.gov/pubmed/16316316/

    [47] 吕丛仪, 李冰, 杨鹏.藻蓝蛋白/羧甲基壳聚糖纳米微球的制备及其对人宫颈癌HeLa细胞增殖的抑制[J].中国肿瘤生物治疗杂志, 2015, 22(1): 34-40. doi: 10.3872/j.issn.1007-385X.2015.1.006

    Lyu CY, Li B, Yang P. Optimized preparation of novel C-phycocyanin-carboxymethyl chitosan nanoparticles and its inhibitory effects on human cervical carcinoma HeLa cells proliferation[J]. Zhongguo Zhong Liu Sheng Wu Zhi Liao Za Zhi, 2015, 22(1): 34-40. doi: 10.3872/j.issn.1007-385X.2015.1.006

    [48] 殷启风, 杨鹏, 王玉娟, 等.新型羧甲基壳聚糖包裹C-藻蓝蛋白负载CD59配体的靶向纳米微球的制备及其对HeLa细胞的杀伤作用[J].中国肿瘤生物治疗杂志, 2017, 24(2): 127-33. doi: 10.3872/j.issn.1007-385X.2017.02.005

    Yin QF, Yang P, Wang YJ, et al. Preparation of novel nanoparticles of carboxymethyl chitosan covered with C-phycocyanin carrying CD59sp and its killing effect on HeLa cells[J]. Zhongguo Zhong Liu Sheng Wu Zhi Liao Za Zhi, 2017, 24(2): 127-33. doi: 10.3872/j.issn.1007-385X.2017.02.005

    [49]

    Wang Y, Jiang L, Yin Q, et al. The Targeted Antitumor Effects of C- PC/CMC-CD59sp Nanoparticles on HeLa Cells in Vitro and in Vivo[J]. J Cancer, 2017, 8(15): 3001-13. doi: 10.7150/jca.21059

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出版历程
  • 收稿日期:  2017-11-19
  • 修回日期:  2017-12-24
  • 网络出版日期:  2024-01-12
  • 刊出日期:  2018-06-24

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