Risk Factors for Death of Advanced Lung Cancer Patients with Lung Infection
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摘要:目的
分析肺癌伴肺部感染患者死亡的相关危险因素。
方法回顾2010年1月—2017年5月收治的186例晚期肺癌患者临床资料，其中肺部感染死亡者52例，并收集肺部感染死亡的相关危险因素。
结果晚期肺癌患者肺部感染死亡率为27.96%（52/186）。在诸多因素中，年龄（P=0.039）、BMI值（P=0.000）、组织分化程度低（P=0.003）、功能状态评分（P=0.022）、转移部位≥3（P=0.029）、合并症（P=0.034）、多重耐药菌感染（P=0.000）、血红蛋白浓度 < 90 g/L（P=0.014）等在死亡组和非死亡组之间差异具有统计学意义。
结论年龄（≥60岁）、BMI值（< 20 kg/m2）、组织分化程度（低）、抗肿瘤治疗药物（≥3种）、靶向药物治疗、转移部位（≥3）、合并症、多重耐药菌感染、血红蛋白浓度（< 90 g/L）等是晚期肺癌患者肺部感染死亡的主要危险因素。
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关键词:
- 肺癌 /
- 肺部感染 /
- 死亡 /
- 危险因素 /
- Logistic回归分析
Abstract:ObjectiveTo analyze the risk factors of death in lung cancer patients with pulmonary infection.
MethodsFrom January 2010 to May 2017, 186 advanced lung cancer patients were treated, among which 52 patients with pulmonary infection died. Risk factors for the death of pulmonary infection were collected.
ResultsThe mortality rate of lung infection in advanced lung cancer patients was 27.96% (52/186). The differences of age (P=0.039), BMI value (P=0.000), low degree of differentiation (P=0.003), functional status score (P=0.022), ≥3 metastatic sites (P=0.029), complications (P=0.034), multiple resistant bacteria infection (P=0.000), hemoglobin concentration < 90g/L (P=0.014) between the death group and survival group were statistically significant.
ConclusionAge (≥60 years old), BMI value (< 20kg/m2), histological grade (low), anti-tumour drugs treatment (≥3 regimens), targeted drug therapy, metastatic sites (≥3), complications, multiple resistant bacteria infection, hemoglobin concentration (< 90g/L) are the main risk factors for the death of advanced cancer patients with pulmonary infection.
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Key words:
- Lung cancer /
- Lung infection /
- Death /
- Risk factors /
- Logistic regression analysis
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表 1 晚期肺癌肺部感染菌种分布及检出构成比(%)
Table 1 Distribution and detection of lung infection bacteria in advanced lung cancer patients (%)
下载: 导出CSV
表 2 肺癌患者肺部感染死亡危险因素情况表(n)
Table 2 Risk factors for death of lung cancer patients with lung infection (n)
下载: 导出CSV
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