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摘要:
1920年Otto Warburg首次提出肿瘤细胞即使在氧气充足的情况下依旧以糖酵解方式提供能量。目前，越来越多的证据表明，肿瘤细胞的糖酵解通路与肿瘤的发生发展具有密切联系，靶向于糖酵解相关酶类及其转运体的药物可通过引起肿瘤周期阻滞，诱导肿瘤细胞凋亡，调节细胞自噬以及抑制肿瘤的转移等途径起到显著的抗肿瘤作用，大量的糖酵解相关酶类及转运体均可作为癌症治疗的候选靶标。本文主要讨论了近年来所报道的靶向于糖酵解途径药物的研究进展，并对其抗肿瘤作用加以总结和展望。
Abstract:In 1920 Otto Warburg firstly described that even in the presence of ample oxygen, cancer cells prefer to metabolize glucose by glycolysis, which named as "Warburg effect". There are growing evidence supporting that the glycolysis pathway of cancer cells is closely associated with the tumorigenesis and development. The drugs targeting glycolytic enzymes and transporters can have an obviously anti-tumor effect by inducing tumor cells cycle arrest, apoptosis, regulating the autophagy of cancer cells and inhibiting the metastasis of the tumor. Many glycolytic enzymes and transporters can be suitable candidate targets for cancer therapy. The review is focused on the inhibitors of glycolysis reported in recent years, summerizes and outlooks the anti-tumor effect of these drugs.
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Key words:
- Metabolism /
- Glycolysis /
- Anti-tumor
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