食管癌中S-100蛋白阳性Langerhans细胞的形态学观察
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摘要: 通过抗S-100蛋白抗体A B C免疫组化方法观察分析了27例人食管鳞状细胞癌组织中S-100蛋白阳性Langerhans细胞的形态及分布。结果显示在食管癌发生中的正常粘膜上皮、不典型增生上皮、原位癌和各级鳞状细胞癌组织中均有该细胞分布。Langerhans细胞表现为分枝或未分枝两种形态。其形态随病变的不同而有所改变。癌组织中的Langerhans细胞与癌细胞、淋巴细胞密切接触,其中部分癌细胞发生退行性改变。提示S-100蛋白阳性Langerhans细胞参与机体抗肿瘤免疫反应。
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关键词:
- 食管癌 /
- Langerhans细胞 /
- S100蛋白
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1 Cocchin IJ, et al. Immunohi8toahemical and immunocytochemical localization of 5-100 antigen is normal human skin. Nn-lure, 1981,294:815 2 Katz SI, et al. The role of lagerhsas cells in antigen presentation.J Invest Dermatol,1985,85:965 3 Nakajima T, et al.S-100 protei。一positive langerhans cell in virous human lung can-cers, espicially in peripheral adenocaciao-ma, Virchows Arch A. 1985,407:171 4 Tay SK, et al. Subpopolation of langerhaascellf is cervical aeoplasia.Br J Ob-flet CvneCOl.1989_9d:16 5 AlcalayJ,ets1.Variations is the number and morphology of langerhans cells in the epidermal component of squamous cell carcinomas, Arch Dermatol, 1!D89, 125:917 6 Tsujitaai S, et al.Langerhans cells and prognosis in patients with gastric carciao-ma, Cancer. 1987, 59:501 7 Ambe K, et al. S-loo protein-positive dentsitic cells is colorectal ada:nocarcinoma,Distribution and relation to the clinical prognosis, Cancer, 1989, 63:496 8 Caorsi I, et al.Lange山any cells in squamous exocervical carcinoma:a quantitative and altrastructural study, Ultra Pathol, 1984,7:25 9 Meissner K. et al.Quantitative analysis of T6-positive langerhans cells in human skincancers, Virchows Arch A, 1986. 410:57 10 Murphy GF, et al.Association of basal-lam-iaa defects with epidermal and dermal T6-positive cell:evidence of laagerhans一cellmigration.Arch rermatol 1es.1985,278:126 11 张云汉,等.ATP酶 fH性LanE; erhans细胞在食管癌发生中的形态学及定址观察。河南肿瘤杂志。
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