Abstract: 53 cases of advanced breast cancer were divided into three groups according to the treatment.There were routine endocrine therapy group (22 cases)，tamosif en group (15 cases) and a minoglutethimide group (16 caser).Estrogen receptors(ER1 and progesteron receptors (PgR) we:e detected in the tumours of all patients by fluoroh- istochemical method, The effective rates of three endocrine therapy groups in ER-post ive patients were 76.9%，77, 8%，81.8%espectively, There were no statistically significant differences among three groups (P>0,05).The effective rates in ER- aegative patients were 0-10%.There were statistically signifticant difference between the effective rates and the levels of estro gen receptors (P < 0,001.The higher the level of the recepror, the higher the effective rate