隆突性皮纤维肉瘤37例临床分析

A Clinical Analysis of 37 Cases Dermatofibroma Protuberans

摘要: 自1977年7月至1989年10月共收治隆突性皮纤维肉瘤病人37例,根据治疗方法分为单纯手术组(S)和手术+放疗组(S+R)。两组的3、5、7、10、15年生存率各为:S组86.4%、86.4%、63.6%、54.5%、45%及S+R组100%、93.3%、80%、60%、33.3%,两组生存率比较,仅15年生存率有意义(P<0.05)。不论是首次治疗还是复发后再治疗,S+R组的5年无瘤生存率均优于S组(P<0.01)。肿瘤最大径<7cm预后较好。本病治疗主张作扩大肿块切除,术后提倡放疗。

Abstract: From Jul 1977 to Oct 1989.37 cases of dermatofibroma protuberans(DFP)were treated either with surgery alone (S)or with surgery plus radiotherapy (S+R).The 3, 5, 7, 10, 15-years survival rates in two groupswere;S group 86.4%, 86.4%，63.6 %, 54.5%，4.5%and SCR group 100%, 93.3%，80%, 60%,33.3%Onlythel5-year survival rate was significant for the S+R group as compared to the S group. The 5-year disease free survival rate was significantly better for the S+R group as compared to the S group (P<0.01)either the first therapy or the secondary therapy after recurrence.The prognosis was better when the maximum tumor size was smaller than 7cm.Radiotherapy is recommended after expansive ontological resection in the light of the treatment of DFP.