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动脉灌注顺铂放射增敏治疗晚期宫颈癌近期疗效观察[J]. 肿瘤防治研究, 1999, 26(2): 140-141.
引用本文: 动脉灌注顺铂放射增敏治疗晚期宫颈癌近期疗效观察[J]. 肿瘤防治研究, 1999, 26(2): 140-141.
A Clinical Trial of Cisplatin in Combination with Radiation Therapy in Advanced Cervical Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(2): 140-141.
Citation: A Clinical Trial of Cisplatin in Combination with Radiation Therapy in Advanced Cervical Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(2): 140-141.

动脉灌注顺铂放射增敏治疗晚期宫颈癌近期疗效观察

A Clinical Trial of Cisplatin in Combination with Radiation Therapy in Advanced Cervical Cancer

  • 摘要: 本文对26例晚期宫颈癌放射治疗疗效进行近期临床观察。所有病例均经病理学证实。26例病人分为两组:放射增敏组和对照组,其中11例病人行动脉灌注顺铂放射增敏,15例行单纯放射治疗。对增敏组11例患者共行24次动脉灌注顺铂加栓塞治疗。所有病人皆接受根治性放疗。结果显示:放射增敏组的放疗半量、全量疗效皆优于对照组(P<0.05),放疗达PR、CR时的顺铂增敏比分别为134和118,同时也可看到较轻的副作用如恶心、呕吐等。

     

    Abstract: 23 patients with advanced cervical cancer histologically proven were evaluated for response after treatment.They were divided into two groups: 1)radiosensitizing group(cisplatin plus irradiation, 9 pat Tent s),2) control group(radiotherapy alone, 14 patients),cisplatin was administered by intraarterial infusion to enhance radiosensitivity. 21 times of treatment were performed in the radiosensitizing group. All patients received radical radiotherapy to the tumor. The result show that the response rate of prim ary tumor in racliosensitizing group w as higher than in control group at the half close or fall close of the treatment, the difference was statistically significant(P<0.05).SER of cisplatin to primary lesion to partial remission and complete remission was 1.35 and 1.15 Mild side effects such as nausea, vomitting were ohserved.

     

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