Abstract: Objective To study the clinical meaning of P¹⁶ expression in ovarian cancer. We detected the expression of P¹⁶ in 19 cases of ovarian cancer and 10 cases of normal ovarians by using S-P immunohis to-chemical method. The results showed that in the ovarian cancer group P¹⁶ positive rate was 63.2%,3 cases advanced ovarian cancer were negative expressions and 4 cases Ic were weak positive expressions; and in the norm al ovarians group, the positive expression rate was 80%and weak positive expression rate was 10%.On the basis of above study.the mutation and deletion of P¹⁶ were closely related to recurrence devopement clinical stage and pathological grading of ovarian turner.