Abstract: Using S-P Immunohistochemical methods with micr+ray restoring tissue antigen, we examined the expression of P-qP in 22 primary hepatocarcinoma( PHC)，10 hepatic spongyvascular tumors, 11cirrhosis and 11 normal hepatic tissues. Among samples analysized, P-qP positive was detected in 19(86%)of 22 PHC, 5 of 11 in cirrhosis; P-qP showed minimal and mid positive in 11 normal tissues,while P-qP dyeing in hepatic pathological lesions were different: positive granute of hepatocellular carcinoma(HCC) is mainly in cell menbrane; In M-PHC, Gland cavity endo-menbrance was positive; Cell menbrance,cytoplasm of cirrhosis were min-mid positive;While location of positive granule is cytoplasm in normal hepatic cells, no positive granule in cell menbrance. These results show expression of P-qP in hepatic pathological lesions not only can judge the sensitivity of chemotherapy for cancer Patients, but also the location and intensity of P-qP expression might relate with the development of hepatocarcinoma.