中国拟青霉(Cn80-2)的抗肿瘤作用和毒性

ANTITUMOR ACTIVITY AND TOXICITY OF PAECILOMYCES SINENSIS SP. NOV.(Cn80-2)

摘要: 体内试验表明，Cn80-2菌丝体注射剂对多种动物移植性肿瘤有显著的抑制作用，每天ip20～25mg/kg，连续7～10天，对白血病L₁₂₁₀、P₉₈₈，以及Lewis肺癌有明显抑制效应，但是对小鼠艾氏腹水癌及肉瘤180无效。在体外试验，Cn80-2对人子宫颈癌Hela细胞有直接杀伤作用，IC₅₀为1.25mg/ml，经该药处理的Hela细胞的活体成癌率显著降低。。

Abstract: Cn80-2 is a new species of Paecilomyces,ip 20-25mg/kg 7-10d.markedly prolinged the survival time of leukemia L1210 and P388 bearing mice, and limted the development of Lewis lung carcinoma in C57BL mice, but had no effect on EAC acd S180. In vitro,Cn80-2 caused a direct lethal cytotoxicity on Hela cells, IC50 was 1.25mg/ml. After treated with Cn80-2,the cells did not growth in immuno-nhibition mice to form cancer. Radioautography study showed that when Hela cells were labelled with H-TdR, the average grain counts per cell revealed that the synthesis of DNA was inhibited by Cn80-2.