甲基硝基亚硝基胍诱发小鼠肺癌和注射局部肿瘤的初步观察

THE PRELIMINARY OBSEY VATION OF THE INDUCTION OF THE LUNG CANCER AND MALIGNANCIES OF LOCAL INJECTION REGION BY N-METHYL-N'-NITRO-N-NITROSO GUANDINE IN MICE

摘要: 用甲基硝基亚硝基胍(MNNG)溶液皮下、肌肉注射LACA小鼠。在351天内肺癌诱发率均为85.71%，注射局部诱癌率分别为85.71%和42.85%而未用MNNG的对照组则未见肿瘤生长。此法简单、易行，方便可靠，是建立肺癌模型值得推广的方法之一。 MNNG不仅是一个局部致癌物质，同时还是一个诱发肺肿瘤的强致癌物质。

Abstract: The N-METHYL-N'-NITRO-N-NITROSO guanidine(MNNG) solution was given by suncutaneous and intramuscelar injections in LACA mice. Theinduction rates of lung adenocaarcinoma by the both kinds of injection were 85.71% within 351 days.But the injected rates of the malignancies of the local regions were 85.71% and 42.85% respectively.There was no tumor induced of control group whicn without MNNG injection. This is siple,ealiable method to induce the experimental lung adenocarcinoma model in mice.So MNNG is not only a local ragion carcinogen, but also a strong carcinogenic sunstance for inducing lung cancer.