甲状腺癌中免疫活性细胞亚群的原位分析

THE IMMUNOCOMPETENT CELLS IN THE THYROID CARCINOMA;A CLINICAL ANALYSIS

摘要: 应用免疫组化ABC方法,我们对30例甲状腺癌和21例甲状腺良性病变组织中浸润的免疫活性细胞进行了单克隆抗体（Leu4、OKT₄、OKT₈、B₁、M718）的原位标记。结果显示甲状腺癌内浸润的单个核细胞（MNC）主要为T细胞和巨噬细胞及少量B细胞。OKT₄/OKT₈为1.35。M718⁺多核巨噬细胞在局部组织内存在为甲状腺癌的特征之一。相反,甲状腺良性病变内MNC量很少。本研究提示MNC和多核巨噬细胞的浸润与癌的类型及病人预后有关。

Abstract: Immunocompetent cells infiltrated into the thyroid carcinoma (30 cases) and benign thyroid lesions (21 eases) were studied by monoelonal, antibodies (Leu4, OKT4, OKT8, B1, M718) with ABC method. The majority of mononuclear cells (MNC) infiltrated into the thyroid carcinomas were T cells and macrophages and the minority was B cells. The ratio of OKT4/OKT8 was 1.35. The existence of M718~+ multinucleated macrophages in the tissues was one of the characters of thyroid carcinoma. In contrast, MNC in benign lesions was rare. We suggested that the infiltrating of MNC and multinucleated macrophages were related with the types of carcinoma and the prognosis of patients.