Abstract: I'ibronectin (FN) and laminin (LN) in cases with gastric adenocarcinoma were studied histologically by immunogoldsilver staining method. some specimens showed positive reactions of EN and/or LN. The positive rate of FN in the cyto'plasma of poo r differentiated carcinoma was higher than that of well differentiated carcinoma, There was no relation between metastasis of carci-soma and positive rate of FN and LN. liN was abundant in tumour stroma, and LN located mainly in the basement membranes of the carcinoma and blood vessels. We believe that there is a correlation between the distribution of FN and LN in tumour cells. With reference to the muco-staining classification，the positive rate of FN in cytoplasma is higher in gastric types and lower in intestinal types.