111例胃癌CEA的免疫组化与预后关系

THE RELATIONShIIP BETWEEN PROGNOSIS AND IMMUNO-HISTOCHEMISTRY OF CEA IN GASTRIC CAREINOMA:111 CASES

摘要: 本文对111例胃切除标本的组织采用ABC免疫酶标技术进行癌胚抗原的反应观察及其预后关系的研究。结果表明：乳头状腺癌，管状腺癌，粘液癌主要为CEA（+），低分化癌、未分化癌与印戒细胞癌为CEA（++）。乳头状腺癌，管状腺癌以CEAⅡ型分布为主，其它类型以Ⅰ型分布为主。肿瘤组织中CEA的含量与肿瘤的淋巴结转移呈正比。在CEA反应不同的三组中，五年存活率有显著的差异。无淋巴结转移时，以CEA（-）组存活率最高;有淋巴结转移时，以CEA（+）组存活率最高;各组均以CEA（++）组存活率最低。

Abstract: Gastric cancer specimens obtained fro m 111 patients who had undergone surgery were stained for carcinoembryonic antigen (CEA) by the avidinbiotin-perogidase complex (ABC) method. These findings suggest that CEA rectivity can be used as a diagnostic and prognostic marger for gastric carcinoma. The petients without lymph node metastasis 5-year survival rate was high especially in the CEA(-)group (81.82%), the survival rate of the CEA(+) group and the CEA(++) group were 53-97% and 10.95%. The patients with lymph node metastasis 5-year survival rate was low in the CEA(++) group. The survival rate of the CEA(++) group CEA(-) and CEA(++) group was 60%, 20.2% and 4.5%, respectively.