胃癌ER与PNA、PHA的表达及其相互关系

The exprssion of ER PNA and PHA in gastric cancers in the relation

摘要: 应用ABC免疫组化法对51例胃癌组织进行雌激素受体（ER）、花生凝集素（PNA）、菜豆凝集素（PHA）检测。结果表明：胃癌组织ER总阳性率为33.33%,多为高分化管状腺癌，与患者性别无明显关系。ER与PNA、PHA在高分化胃癌中表达趋于-致，但在低分化胃癌中存在差异，提示雌激素对胃癌的发生发展有-定的依赖性，与PNA、PHA受体的表达亦有-定的相关性，提供了胃癌组织的生物学和肿瘤免疫病理学特征。

Abstract: Using Avidn-biotiog-peroxidass complex (ABC) immunohisto-chemical methed, 51 gastric cancer specimens were examined for Estropen Receptors (ER)，Peanut Agglutinin (PNA) and Phaseolus Vulgaris Agglutinin (PHA). The results showed that ER was present in 17 (33. 33 0 0 ) of gastric cancers. The ER positive tissues were cbiefly well-differentiated gastric cancers. There were no signigcanl statistical differences in the patient's sex and the ER positive rates. The expression of ER was consisten with PNA and PHA in well-diffrentiated gastric cancers, but the difference in pool-differentiated ones. It reveal that ER has leupencent upon the development for occurrence of gastric cancers and similanly relatively to expression of PNA PHA receptors. It reflects the feactures on biology and oncological immunopathology in tissue of gastric cancer.