原发性食管小细胞未分化癌5例报告及文献综合分析

Primary Small Cell Undifferentiated Carcinoma of the esophagus

摘要: 原发性食管小细胞未分化癌少见.本文对从国内文献收集的137例加上本院的5例共142例进行分析.发病年龄以50~60岁多见,男女之~为3.79:l,肿瘤长径范围为1.2~15cm,平均5.6cm.病变发生于食管上1/3者10例(7.5%)、中1/386例(64.2%)、下1/338例(28.3%).髓质型50例(41%)、蕈伞型26例(21.3%)、溃疡型24例(19.7%)、腔内型16例(13.1%)、缩窄型6例(4.9%).统计国内文献各该组发病率为0.7%~5.1%,本院组为0.1%.本病预后主,在可评价疗效的131例中,中位生存期和1年生存率:全组为7.6个月和29%;单纯手术6.3个月和18.4%;单纯放疗11.8个月和36.6%;放疗加化疗12.3个月和50%;手术加化疗12.2个月和39.3%.单纯化疗和手术加放疗中位生存期分别为5.5个月和5个月,无1年生存者.根据资料,作者认为使用放疗或根治性手术加用化疗可以提高本病的疗效.

Abstract: caseg of primary small cell undifferentisted carcinoma of the esophagus were analysed.137 were collected from the domestic Literature and 5 are added by the authors. The tumor occurred more frequently in patients 50-60 years old. The male to female sex ratio was 3. 79 1 1'On basis of the present data, the authors believe that the survival rate of the disease may be increased by the combination of radiation ot radical resection and systemic chemotherapy.