癌胚抗原、上皮细胞膜抗原及Ⅳ型胶原与胃癌分化、浸润和转移的关系

癌胚抗原、上皮细胞膜抗原及Ⅳ型胶原与胃癌分化、浸润和转移的关系

Immunohistochemical localiations of the carcinoembrynic antigen，epithelial membrane antigen and IV type collagen of stomach carcinoma in relation to differentiation invasion and metastasis

摘要

摘要: 本文应用免疫组化方法对66例胃癌组织内CEA、EMA及ColⅣ的含量及分布进行了观察，用以探讨CEA、EMA及ColⅣ的表达与胃癌分化、浸润及转移的关系。结果表明：正常胃粘膜上皮细胞CEA及EMA阴性，ColⅣ见于胃腺管基底膜内，呈连续线状。分化型癌具有较强合成EMA及ColⅣ的能力（EMAP<0.05；ColⅣP<0.01）。随胃癌侵袭能力的增加，CEA含量明显增加（P<0.05；P<0.01），ColⅣ含量明显减少（P<0.05）。术后呈恶性经过的胃癌，ColⅣ含量有降低的趋势，但差异无显著意义（P>0.05）.作者认为正常胃粘膜与胃癌组织CEA、EMA及ColⅣ含量及分布上的差异，使之可能成为临床诊断胃癌，判断其分化程度的有用指标。CEA含量增加和/或ColⅣ含量减少的胃癌，恶性度较高，侵袭力较强，预后较差。

Abstract: The localizations of CEA, EMA and Col Ⅳ in 66 cases of stomach carcinomas were observed with ABC method to investigate the relation between the expression of CEA，EMA and Col Ⅳ and the differentiation，invasion and metastasis of stomach carcinoma. The results showed there were no CEA and EMA reaction in normal stomach mucosa, Col Ⅳ was localized in the basement membrane of stomach gland. The differentiated type cancer had the stronger ability of EMA and Col Ⅳ synthesis (EMA P<0.05; Col Ⅳ P<0.0l). As the invasion of stomach carcinoma increased, CEA reaction increased apparently (P<0.05), Col Ⅳ reaction decreased apparently (P< 0.0l). The authors considered the difference of CEA，EMA and Col Ⅳ between normal stomach mucosa and stomach carcinoma make it possible to become useful tools in clinically diagnosising stomach carcinoma and determining its differentiated degree. The stomach carcinomas with more CEA and/or less Col Ⅳ invade and metastasis more easily.

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