AgNOR在纤维源性肿瘤鉴别及预后中的意义

PROGNOSTIC SIGNIFICANCE AND DIFFERENTIATION OF AgNOR IN FIBROGENIC NEOPLASM

摘要: 本文对88例纤维源性肿瘤进行了核仁形成区蛋白定量研究,其中纤维瘤6例,瘤样纤维组织增生45例,纤维肉瘤37例.结果表明三种病变及其亚类核仁形成区蛋白均值有显著与高度显著性差异(P<0.05,P<0.001).在随访的34例纤维肉瘤患者中,高核仁形成区蛋白均值患者(≥5)的生存时间显著短于低均值(<5)患者(P<0.05),5年生存率分别是20%与53%.因此,作者认为核仁形成区蛋白在鉴别纤维源性肿瘤及预测患者预后中均有一定实用价值.

Abstract: The argyrophilic nucleolar organizer region (AgNOR) of 88 cases with fibrogenic neoplasmwere quantitatively investigated, which included 6 cases of fibroma, 45 fibromatoid hyperplasia and37 fibrosarcoma. The results showed that a significant difference was found in the mean of AgNORamong three lesions and their subgroup (P0. 05, P0.001), and the survival time of the cases with a high AgNOR mean (≥5) was significant shorter than those with a low AgNOR mean (5) in 34 cases with librosarcoma followed up five years (P0. 05), and the 5-year survival rateswas 20% and 52% respectively. Therefore, the authors concluded that AgNOR has certain practical value for differentiating fibrogenic neoplasm and predicting the patients' prognosis.