Abstract: Abstract Chemotherspy, immunotherapy and immunochemotherapy were tested for thire effects on NK-IL-2-IFN-r in 46 patients with advanced cancer. The results showed that (1) the NK, IL-2 andIFN-r activities in the cancer patients were significantly lower than those in controls;(2) both be- fore and after chemotherapy there were no apparently changes in the NK, IL-2 and IFN-r activityexcept for WBC; (3) the immune indexes were apparently increased after immunotherapy and immunochemotherapy as compared to those before, and (4) the IL-2 and IFN-r activity in immunochemotherapy group were significantly higher than chemotherapy and immunotherapy grouprespectively, but the NK activity in immunochemotherapy group was significantly than that only inchemotherapy group and the IL-2 activity and WBC in immunotherapy group were apparentlyhigher than those in chemotherapy group. It is concluded that the immune function in the host canbe restored by adiministrating iRNA and S-TF, and either the side effects of chemotherapy can bereduced or an synergistical immunoregulation of NK-IL-2-IFN-r aganist cancer can be enhanced inthe patients by combining chemotherapy with iRNA and S-TF.