骨肉瘤的大剂量化治疗
High Dose Chemotherapy for Osteogenic Sarcoma
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摘要: 本文报告HDMTXCFR治疗原发性骨肉瘤18例的临床疗效，所有病例除一例经X线诊断外，余经病理学确诊。MTX每疗程荆童0. 5～3.0/M2,静滴MTX开始至CF解救时间为16^} 18小时，其毒副反应轻，无一例发生意外。骨肉瘤术后辅助化疗后2年生存率55.600，生存5年以上者3例。本文提示，骨肉瘤的辅助化疗有肯定疗效，HDMTX为有效的辅助化疗方案之一，但剂t不宜过低，只要注意水化，尿碱化及CF解救，此疗法是安全的。Abstract: 18 cases of osteogenic sarcoma treated with high-dose methotrexate(HDMTX)in our hospitalfrom 1988 to 1993 are reported，which were proven by histopathology except one by X-ray.HDMTX was administrated to all patients at a dose of 0. 5 g/m to 3. 0 g/m with intravenous hy-dration and alkalization. Leucovorin was begun 16 to 18 hours after the start of the methotrexateinfusion at a dose of 12 mg every 6 hours for three days. The 2-year overall survival was 55.600(10/18)for patients with osteogenic sarcoma after receiving postoperative HDMTX chemotherapyand the 5一year overall survival 15. 2%(3/18).The report suggests that the value of adjuvantchemotherapy for osteogenic sarcoma seems well established，HDMTX is one of the effective adj-vant chemotherapy regimens and considerably less toxic when administrated with appropriatedose, hydration, alkalinization，and leucovorin rescue.
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Key words:
- Methotrexate /
- Leucovorin /
- Osteogenic Sarcoma /
- Adjuvant Chemotherapy
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