移植性小鼠宫颈癌和增生组织中HSV－2抗原的检测

Examination of HSV-2 Antigen in Autoplastic Cervical Cancer and Proliferated Tissues in Mice

摘要: 本实验采用敏感性较高的PAP法检测了HSV-2诱发的移植性小鼠宫颈癌和增生组织中的HSV-2抗原。结果30例HSV-2诱发的增生或癌组织中有24例阳性，阳性率达80%。14例经HSV-2处理的非增生、非癌性宫颈组织中4例阳性，阳性率为28.57%。两组阳性率有显著性差异(P<0.01)。本实验在改良了传统的诱癌模型情况下，检测了HSV-2抗原的表达并进一步确立了HSV-2在实验性小鼠宫颈癌发生中的作用。

Abstract: In this experiment,HSV-2 antigen in autoplastic cervical cancer and proliferated tissues of mice induced by HSV-2 virus were detected with highly sensitive PAP method.The results showed 24 cases,were positive in 30 proliferated or cancer tissues induced by HSV-2,which positive rate was 80%.However,in 14 non-proliferateod and non-cancer cervical tissues,only 4 cases were positive,positive rate was 28. 57 %.There were significant difference between positiue rates of the two group(P0. 01).In modified model of induced cancer, the study investigated the expression of HSV-2 antigen and further verified that HSV-2. plays a certain role in experimental cervical cancer in mice.