类固醇激素治疗脑肿瘤时的肌无力

Weakness in Brain Tumor Patients Treated with Steroid

摘要: 在204例用类固醇激素治疗的脑肿瘤病人中，25例（12.3%）发生了类固醇肌病（SM）,它主要发生在用类固醇激素治疗后4-7周。Wilcoxon检验表明发生了SM与没发生SM的病人所用类固醇激素的总剂量没有明显差异，这提示在SM的发生上，个体对类固醇激素的易感性起了重要作用。同时服用了抗癫药物的病人，SM的发生率（7.9%）明显低于没服用抗癌药的病人（21.9%）.

Abstract: Steroid myopathy (SM) occured in 25(12. 3%) of 204 patients with brain tumors who received steroid therapy and most of them developed weakness during the 4th through 7th week of continous steroid treatment. Wilcoxon test showed that there was no significant difference in the cumulative steroid dose between patients with SM and the patients without SM. It suggested that differences in individual susceptibility to the effects of steroid play a major role in the occurence of SM. The risk of developing SM was significiently lower in patients taking antiepileptic drugs (7. 9% ) than in patients who were not taking antiepileptic drugs.