小肝癌的雌激素、孕激素受体研究

Study on the receptor of estrogen and progesterone in small hepatocellular carcinoma

摘要: 本研究用酶联亲和组化法检测41例（男35例、女6例）有临床随访资料的原发性小肝癌（SHCC）患者的肝癌组织及癌旁肝组织中雌激素受体（ER）、孕激素受体（PR）的分布情况。结果表明癌组织ER、PR显色强度明显低于癌周肝组织（P<0.01）.PR、ER的阳性率与癌组织分化程度无相关性，但与患者存活时间有明显关系，存活时间较长组ER、PR的阳性率较高（P<0.05）.本结果为探索用内分泌抗激素治疗肝细胞癌提供一定的观察依据。

Abstract: The distributions of the receptor of estrogen (ER) and progesterone (PR)within liver cancerous and their surrounding tissues were studied by the enzyme linked affinity histochemistry in 41 cases of SHCC (male 35 cases, female 6 cases)which were followed up for years. The results showed that the staining reaction of ER and PR were weaker in cancerous tissues than their surronding liver tissue (P0. 01). There is no relationship between the positive rate and the different degree of carcinoma, but the positive rate of ER and PR were connected with the survival time. The positive rate of ER and PR is higher in the group with longer survival time. The results provide the basic theory for the probing into the therapy methods of HCC with anti-Hormone in some way.