抗胃癌单抗在肾包膜下荷人胃癌移植瘤裸小鼠体内生物学分布

The Biodistribution of Anti-gastric Carcinoma Monoclonal Antibody in Nude Mice Bearing with Transplanted Human Gastric Carcinoma Under Subrenal Capsules

摘要: 本人报道胃癌单抗MGb₂和MG7用¹²⁵I标记后, 观察它们在左右肾包膜下分别接种SGC-7901与GAⅡ移植瘤的裸小鼠体内的生物学分布。结果表明, 腹腔注射¹²⁵I-MGb₂(40uci/7.4ugMGb₂/小鼠)后96小时．SGC－7901和GAⅡ移植瘤与血的T/NT值分虽为1.03和1.57。而腹腔注射¹²⁵I－MG₇(40uci/7.4ugMG7/小鼠后96小时, 两移植瘤组织与血的T／NT值分别为0.31和1.53。

Abstract: The biodistribution of two ¹²⁵I-labelled anti-gastric carcinoma monoclonal antibodies (¹²⁵I-MGb₂ and MG₇) in nude mice bearing with two transplanted human gastric carcinoma (SGC-7901 and GA Ⅱ) under subreal capsules has been studied.Nude mice inculated with GA Ⅱ In rlght lateral Subreal Copsules 10 days earlier were transplanted the SGC-7901 in left lateral subreal capsules. 5 days later, the nude mice were treated i. p. with single ¹²⁵I-Mgb₂40uci/7.4ug MGb₂/mouse. 96 hr after the administration, the radioactively, while the mice treated i. p. with 40uci/7.4ugMG₇/mouse, thay were 0.31和1.53, respectively.