肺腺鳞癌的病理和生物学特性
Surgical treatment of adenosquamous carcinoma of the lung
-
摘要: 本文报告了外科治疗肺腺鳞癌102例, 占同期肺癌的10%。 临床特点为侵袭力强, 早期转移, 进展猛烈等低分化癌特征, 其粘膜下浸润较远为其他类型肺癌所罕见。 周围型肿瘤距支气管切缘1～5cm, 组织学切缘受侵者达到25.3%; 3、5年生存率为16.4%及8.9%, 较其他类型肺癌明显偏低。 因此可以认为其是一种预后最差的低分化混合癌。 其腺、鳞癌两种恶性成分比例肿瘤大小有关即肿瘤越大, 鳞癌成分越多。 本文提供了肺腺鳞癌的诊断标准及其理由。 早期诊断外科手术治疗效果良好, 对中晚期病例应行以手术为主之综合治疗。Abstract: This article reported 102 cases of adenosquamous carcinorna of the lung treated surgically, which was 10%, of the total patients admitted with lung cancer in the same perlod. lt's clinical features were easy to lnvade adjacent organ, early spread and the disease became soon, representing poorly differentiated cancer. The longer invasion of the tumor beneath the bronchial mucous membrane is rare in other pathological types. of 25.3% the resected bronchial edge far from the tumor in 1 to 5cm in peripherlal lung cancer was invaded pathologically. The 3 and 5-Year'ssurvival rate was 16.4% and 8.9% poorer than others. It was considered as a mixed poorly differentiated tumor, then having poorer prognosis. The ratio of the two kinds of malignant cell is related to the volume of the tumor. It was said that the bigger size the tumor ls, the more squamus cell have. The diagnostic standard and the reason was disscused. If the tumor was resected radically in early stage,good result may be obtained. But in the modera1ely and late stage, surgery combined with chemotherapy and radiotherapy should be used.
-
Key words:
- Lung tumor /
- Adenosquamous carcinoma /
- Surglcal treatment
-
-
[1] WHO. Histological typing of lung tumors. Am J Clin Pathol. 1982. 77:123. [2] Fitzgibbons PL, Kern WH. Adenosquamous carcinoma of the lung:A clinmcal and pathologic study of 7 cas-es. Human Pathology, 1985, 16:463. [3] 于蛹华, 吕奇山, 肺鳞腺混合癌2例. 肿瘤防治研究, 1994, 21:151. [4] McDowell Em. Hess FG. and Trump BF. Epidermoid metaplasia, carcinoma in situ and carcinoma of the lung. Diagnostic electron microscopy. Vol 3. New York:Joho Wiley and Sons. Inc. 1980. [5] 李维华, 阎培莎. 分化差的肺癌超微结构研究. 解放军医学杂志, 1986, 11:248. [6] 彭延生, 蔡执敏, 潘晓东, 等. 223例肺腺鳞癌的外科治疗分析. 中华结核和呼吸杂志, 1991, 14:165. [7] 黄志英, 徐佩钦, 周冕. 1286例支气管肺癌病理变化与预后. 结核病与肺部肿瘤, 1988. 3:9. [8] 单远, 李维华. 肺腺鳞癌的光镜与电镜研究. 临床与实验病理学杂志, 1992, 8:186.
计量
- 文章访问数: 2341
- HTML全文浏览量: 57
- PDF下载量: 442
下载:
