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不同分割照射同时化疗对人肺腺癌的杀伤作用[J]. 肿瘤防治研究, 1997, 24(3): 160-162.
引用本文: 不同分割照射同时化疗对人肺腺癌的杀伤作用[J]. 肿瘤防治研究, 1997, 24(3): 160-162.
The Influence of Different Fractionated Irradiation Conc-omitant with Chemotherapy on Human lung Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 1997, 24(3): 160-162.
Citation: The Influence of Different Fractionated Irradiation Conc-omitant with Chemotherapy on Human lung Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 1997, 24(3): 160-162.

不同分割照射同时化疗对人肺腺癌的杀伤作用

The Influence of Different Fractionated Irradiation Conc-omitant with Chemotherapy on Human lung Adenocarcinoma

  • 摘要: 本实验用体外细胞克隆培养和体内实验处理离体细胞克隆培养这两种技术,观察了5-FuDDP联合辐射对人肺腺癌Anip-973细胞及实体瘤的杀伤作用。结果,联合给药+常规分割照射的细胞存活率为9.6%;细胞实验的剂量修饰因子(DMF)值为2.2,动物实体瘤DMF为2.0;联合给药+超分割照射的细胞存活率为17.3%,细胞实验DMF值为1.9,动物实体瘤为1.5;单纯给药组的细胞存活率为75%;2GY照射的细胞存活率为76.7%。结论:5-Fu+DDP联合照射有明显的协同作用;放-化同时使用时,常规分割照射对肿瘤的杀伤大于超分割照射。

     

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