Abstract:
The effects of iRNA and S-TF on LAK, II-2 activity and IL-2R expression of the advanced primary hepatocarcinoma(PHC) patients were studied.The results showed that(1)the LAK, IL-2 activity and IL-2R expression in PHC patients were significantly declined as compared to those in controls, and between the LAK and IL-2 activity correlated positively;(2)the above indexes of the patients after administration of iRNA and S-TF were apparently higher than those before.The study suggests that the decreased or disordered cellular immune function in the host may be associated with pathogenesis and growth of tumor, moreover, the cellular immune response(IL-2 activity, etc) in the host may be improved under the stimulating of iRNA and S-TF.