骨巨细胞瘤定量诊断与恶性度分级研究

Malignancy Grading and Quantitative Histomorphologic Diagnosis of Giant Cell Tumor of Bone

摘要: 利用图像分析技术（IAT）对51例骨巨细胞瘤（GCT）为研究对象，13例骨囊肿和15例骨肉瘤为对照组，对细胞核（GCT取基质细胞核），DNA含量测定，DNA倍体类型研究，术后复发病例的DNA倍体类型与其传统分级的比较研究。结果发现GCTⅠ级和Ⅱ级之间无显著差别，且它们的生物学属性属潜在恶性和低度恶性范畴，研究还揭示GCT的DNA≥5C细胞数超过10%系术后复发，转移的高危病例。

Abstract: 51 cases of giant cell tumor of bone(GCT) were studied using image analysis technology(IAT),while 13 cases of bone eyst and 15 cases of osteosarcoma were served as eontrol groups.DNA content of the tumorous nuclei(GCT:stromal cell nuelei) was measured in all cases.Their relevant DNA Ploid Patterns were determined.Additionally,the relationships between DNA ploidy with postoperational recurrence of GCT and its conventional grading were evaluated.Statistical analysis on above four aspects showed that there was no significant difference between GCTof grade Ⅰand Ⅱ,and both of there biological properties fell within the categories of potential maligmant and low-grade malignant lesions.The results also indicated that the GCT patient with DNA SC percentage above 10% should be regarded as the high-risk case who is likely to have recurrence and metastasis.