Abstract: Objective :376 patients with pituitary adenoma were treated by transspllenoidal microsurgery in our department between July 1986 and O-ctober 1996.There were 239 females and 137 males.The patients ranged in age from 13 to 67 years with a mean of 38.9 years.Of the patients,152 (40.4%) were macr-oadenomas and 224(59.6%) were microadenomas. Methods :The diagnosis of disease was made by CT or MRI scanning.Operati-ons were performed via either sublabio-septo-sphenoidal approach or nasovestibulo-sphenoidal approach. Results :There were no deaths af-ter operation in this patient group.Long-term follow-up review(median 3.5 years)in 308 patients revealedgood recovery of 258 patients(83.8%), contrasted with a 16.9% late recurrence ratefor macroadenomas(41 cases)and microadenomas(11 cases).This patients with recurrence of tumor need to treat by again operative management,drug therapy,radiotherapy,and radiosurgery used either alone or combined. Conclusion :It is a safe and effective method by used the microsurgical technique via transsphenoidal approach to remove pituitary adenoma.